Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

被引：133

作者：

Hussain, Tarique ^{[1
,2
,3
]}

Tan, Bie ^{[1
,2
]}

Murtaza, Ghulam ^{[4
]}

Liu, Gang ^{[1
,2
]}

Rahu, Najma ^{[5
]}

Kalhoro, Muhammad Saleem ^{[6
]}

Kalhoro, Dildar Hussain ^{[5
]}

Adebowale, Tolulope O. ^{[2
]}

Mazhar, Muhammad Usman ^{[3
]}

Rehman, Zia Ur ^{[7
]}

Martinez, Yordan ^{[8
]}

Khan, Shahzad Akber ^{[9
]}

Yin, Yulong ^{[1
,2
]}

机构：

[1] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China

[2] Chinese Acad Sci, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr,Lab Anim Nutr Physiol & Metab Pr, Changsha 410125, Hunan, Peoples R China

[3] NIAB, Anim Sci Div, POB 128,Jhang Rd, Faisalabad 38000, Pakistan

[4] Shaheed Benazir Bhutto Univ Vet & Anim Sci, Sakrand 67210, Sindh, Pakistan

[5] Sindh Agr Univ, Fac Anim Husb & Vet Sci, Dept Vet Microbiol, Tandojam 70050, Sindh, Pakistan

[6] Asian Inst Technol, Food Engn & Bioproc Technol, Bangkok 12120, Thailand

[7] Huazhong Agr Univ, Coll Anim Sci & Technol 19, Educ Minist China, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China

[8] Pan Amer Sch, Agr Sci & Prod Dept, POB 93, Francisco Morazon, Honduras

[9] Univ Poonch, Fac Anim Husb & Vet Sci, Rawalakot 12350, Pakistan

来源：

PHARMACOLOGICAL RESEARCH | 2020年 / 152卷

基金：

中国国家自然科学基金;

关键词：

T2DM; Oxidative stress; Inflammation and flavonoids; ENDOPLASMIC-RETICULUM STRESS; IMPAIRED GLUCOSE-TOLERANCE; GLYCOGEN-SYNTHASE KINASE-3; INDUCED INSULIN-RESISTANCE; UNFOLDED PROTEIN RESPONSE; INDUCED OXIDATIVE STRESS; BETA-CELL DYSFUNCTION; SKELETAL-MUSCLE CELLS; GREEN TEA CATECHINS; IN-VIVO EVALUATION;

D O I：

10.1016/j.phrs.2020.104629

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction of free radicals where oxidative stress could contribute it. Possible factors are defective insulin signals, glucose oxidation, and degradation of glycated proteins as well as alteration in glutathione metabolism which induced hyperglycemia. Previous studies revealed a link between T2DM with oxidative stress, inflammation and insulin resistance which are assumed to be regulated by numerous cellular networks such as NF-kappa B, PI3K/Akt, MAPK, GSK3 and PPAR gamma. Flavonoids are ubiquitously present in the nature and classified according to their chemical structures for example, flavonols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones. Flavonoids indicate poor bioavailability which could be improved by employing various nano-delivery systems against the occurrences of T2DM. These bioactive compounds exert versatile anti-diabetic activities via modulating targeted cellular naling networks, thereby, improving glucose metabolism, alpha-glycosidase, and glucose transport or aldose reductase by carbohydrate metabolic pathway in pancreatic beta-cells, hepatocytes, adipocytes and skeletal myofibres. Moreover, anti-diabetic properties of flavonoids also encounter diabetic related complications. This review article has designed to shed light on the anti-diabetic potential of flavonoids, contribution of oxidative stress, evidence of efficacy in clinical, cellular and animal studies and nano-delivery approaches to enhance their therapeutic efficacy. This article might give some new insights for therapeutic intervention against T2DM in near future.

引用

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