Protective effects of caffeic acid phenethyl ester on rotenone-induced myocardial oxidative injury

被引：8
作者：
Akpinar, MB
Erdogan, H [1 ]
Sahin, S
Ucar, F
Ilhan, A
机构：
[1] Inonu Univ, Fac Med, Dept Cardiovasc Surg, Malatya, Turkey
[2] Gaziosmanpasa Univ, Fac Med, Dept Physiol, Tokat, Turkey
[3] Gaziosmanpasa Univ, Fac Med, Dept Biochem, Tokat, Turkey
[4] Ankara Numune Training & Res Hosp, Dept Clin Biochem 2, Ankara, Turkey
[5] Inonu Univ, Fac Med, Dept Neurol, Malatya, Turkey
来源：
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 2005年 / 82卷 / 03期
关键词：
rotenone; heart; oxidants/antioxidants; lipid; peroxidation; nitric oxide; CAPE;
D O I：
10.1016/j.pestbp.2005.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rotenone, an insecticide, causes toxicity through inhibition of mitochondrial electron transport chain at complex I and oxidative injury to the tissues. The aim of the present study was to determine in vivo effects of rotenone on myocardium and cardio-protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, against rotenone toxicity in rats. The rats were divided into three groups: untreated control, rotenone (2.5 mg/kg/day for 60 days, i.p.) and rotenone + CAPE groups. CAPE was administrated i.p. 10 ltmol/kg/day for 62 days started two days before first dose rotenone injection. The malondialdehyde, nitric oxide levels and xanthine oxidase activity of rotenone group was significantly higher than control and rotenone + CAPE groups (to < 0.05). However, catalase activity in the rotenone group was decreased in comparison with the other groups (p < 0.05). The superoxide dismutase activity of rotenone group was insignificantly decreased compared to the others. In conclusion, rotenone caused lipid peroxidation in myocardial tissue and CAPE treatment prevented this rotenone-induced lipid peroxiclation in rats. CAPE might be a cardio-protective agent against myocardial toxicities. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：233 / 239
页数：7
相关论文
共 34 条
[1]  
Aebi H., 1974, Methods in Enzymatic Analysis, V2, P674, DOI [DOI 10.1016/B978-0-12-091302-2.50032-3, 10.1016/B978-0-12-091302-2.50032-3]
[2]   Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain [J].
Bashkatova, V ;
Alam, M ;
Vanin, A ;
Schmidt, WJ .
EXPERIMENTAL NEUROLOGY, 2004, 186 (02) :235-241
[3]   Production of reactive oxygen species by mitochondria - Central role of complex III [J].
Chen, Q ;
Vazquez, EJ ;
Moghaddas, S ;
Hoppel, CL ;
Lesnefsky, EJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :36027-36031
[4]  
CORTAS NK, 1990, CLIN CHEM, V36, P1440
[5]  
ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407
[6]   Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats [J].
Fadillioglu, E ;
Oztas, E ;
Erdogan, H ;
Yagmurca, M ;
Sogut, S ;
Ucar, M ;
Irmak, MK .
JOURNAL OF APPLIED TOXICOLOGY, 2004, 24 (01) :47-52
[7]   Effects of caffeic acid phenethyl ester against doxorubicin-induced neuronal oxidant injury [J].
Fadillioglu, E ;
Erdogan, H ;
Iraz, M ;
Yagmurca, M .
NEUROSCIENCE RESEARCH COMMUNICATIONS, 2003, 33 (02) :132-138
[8]  
FADILLIOGLU E, 2003, T KLIN J MED SCI, V23, P366
[9]   CARCINOGENESIS WITH THE INSECTICIDE ROTENONE [J].
GOSALVEZ, M .
LIFE SCIENCES, 1983, 32 (08) :809-816
[10]   The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury [J].
Hosnuter, M ;
Gürel, A ;
Babucçu, O ;
Armutcu, F ;
Kargi, E ;
Isikdemir, A .
BURNS, 2004, 30 (02) :121-125
1234