Unprecedented, fully recyclable, solid-supported reagent for the kinetic resolution of racemic amines through enantioselective N-acetylation

被引：14
作者：
Arseniyadis, S
Subhash, PV
Valleix, A
Wagner, A
Mioskowski, C
机构：
[1] Univ Louis Pasteur Strasbourg 1, Fac Pharm, CNRS, Lab Synth Bioorgan, F-67401 Illkirch Graffenstaden, France
[2] CEA Saclay, Dept Biol Cellulaire & Mol, Serv Mol Marquees, F-91191 Gif Sur Yvette, France
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 26期
关键词：
D O I：
10.1039/b504200c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The high-yielding synthesis and application of the first polymer supported reagent for the kinetic resolution (KR) of amines through enantioselective acetylation is described; this new supported chiral reagent allows the KR of primary amines with excellent selectivities at room temperature; moreover, this supported approach is highly efficient as the Merrifield-supported chiral scaffold can be quantitatively recovered and recycled.
引用
收藏
页码：3310 / 3312
页数：3
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