An efficient organocatalytic route to the atorvastatin side-chain

被引：17
作者：
George, Shyla [1 ]
Sudalai, Arumugam [1 ]
机构：
[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 48期
关键词：
D O I：
10.1016/j.tetlet.2007.09.133
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An organocatalytic route to the synthesis of the atorvastatin side-chain, a building block present in the statin family, is described using L-proline-catalyzed alpha-aminooxylation of an aldehyde. The method also employs an iodine-induced intramolecular electrophilic cyclization of a carbonate to produce the iodocarbonate in a highly diastereoselective manner. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8544 / 8546
页数：3
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