Nanoparticle Delivery Systems in Cancer Vaccines

被引：167

作者：

Krishnamachari, Yogita ^{[1
]}

Geary, Sean M. ^{[1
]}

Lemke, Caitlin D. ^{[1
]}

Salem, Aliasger K. ^{[1
]}

机构：

[1] Univ Iowa, Dept Pharmaceut Sci & Expt Therapeut, Coll Pharm, Iowa City, IA 52242 USA

来源：

PHARMACEUTICAL RESEARCH | 2011年 / 28卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cancer immunotherapy; colloidal nanocarriers; liposomes; polymeric nanoparticles; tumor targeting; BLOOD-BRAIN-BARRIER; T-CELL RESPONSES; LOADED ANTI-HER2 IMMUNOLIPOSOMES; STERICALLY STABILIZED LIPOSOMES; TARGETED PHOTOTHERMAL ABLATION; MAGNETITE CATIONIC LIPOSOMES; SUBCUTANEOUS MURINE MELANOMA; ENTRAPPED SOLUBLE-PROTEIN; ENHANCED IMMUNE-RESPONSE; ANTIGEN-PRESENTING CELLS;

D O I：

10.1007/s11095-010-0241-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Therapeutic strategies that involve the manipulation of the host's immune system are gaining momentum in cancer research. Antigen-loaded nanocarriers are capable of being actively taken up by antigen-presenting cells (APCs) and have shown promising potential in cancer immunotherapy by initiating a strong immunostimulatory cascade that results in potent antigen-specific immune responses against the cancer. Such carrier systems offer versatility in that they can simultaneously co-deliver adjuvants with the antigens to enhance APC activation and maturation. Furthermore, modifying the surface properties of these nanocarriers affords active targeting properties to APCs and/or enhanced accumulation in solid tumors. Here, we review some recent advances in these colloidal and particulate nanoscale systems designed for cancer immunotherapy and the potential for these systems to translate into clinical cancer vaccines.

引用

页码：215 / 236

页数：22

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