Clinical Characteristics and Histopathology of Coronavirus Disease 2019-Related Deaths in African Children

被引：9

作者：

Mabena, Fikile C. ^{[1
,2
]}

Baillie, Vicky L. ^{[1
,3
]}

Hale, Martin J. ^{[1
,4
]}

Thwala, Bukiwe N. ^{[1
,3
]}

Mthembu, Nonhlanhla ^{[1
,3
]}

Els, Toyah ^{[1
,3
]}

Serafin, Natali ^{[1
,3
]}

du Plessis, Jeanine ^{[1
,3
]}

Swart, Peter ^{[4
]}

Velaphi, Sithembiso C. ^{[2
]}

Petersen, Karen L. ^{[2
]}

Wadula, Jeannette ^{[5
]}

Govender, Nelesh P. ^{[6
,7
]}

Verwey, Charl ^{[1
,2
]}

Moore, David P. ^{[1
,2
]}

Moosa, Fatima Y. ^{[2
]}

Nakwa, Firdose L. ^{[2
]}

Maroane, Basetsana, V ^{[2
]}

Okudo, Grace ^{[2
]}

Mabaso, Theodore M. ^{[2
]}

Dangor, Ziyaad ^{[1
,2
]}

Nunes, Marta C. ^{[1
,3
]}

Madhi, Shabir A.

机构：

[1] Univ Witwatersrand, South African Med Res Council, Fac Hlth, Sch Pathol,Vaccines & Infect Dis Analyt Res Unit, Johannesburg, South Africa

[2] Univ Witwatersrand, Dept Paediat & Child Hlth, Fac Hlth Sci, Johannesburg, South Africa

[3] Univ Witwatersrand, Natl Res Fdn, Dept Sci & Technol, Vaccine Preventable Dis Unit,Fac Hlth Sci, Johannesburg, South Africa

[4] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Div Anat Pathol, Johannesburg, South Africa

[5] Univ Witwatersrand, Chris Hani Baragwanath Acad Hosp, Natl Hlth Lab Serv, Clin Microbiol & Infect Dis,Fac Hlth Sci, Johannesburg, South Africa

[6] Univ Witwatersrand, Natl Inst Communicable Dis, Div Natl Hlth Lab Serv, Fac Hlth Sci, Johannesburg, South Africa

[7] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 09期

基金：

英国医学研究理事会; 比尔及梅琳达.盖茨基金会;

关键词：

coronavirus disease 2019; pediatrics; histopathology;

D O I：

10.1097/INF.0000000000003227

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Globally, very few childhood deaths have been attributed to coronavirus disease 2019 (COVID-19). We evaluated clinical, microbiologic and postmortem histopathologic findings in childhood deaths in whom severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified antemortem or postmortem. Methods: Surveillance of childhood deaths was ongoing during the initial COVID-19 outbreak in South Africa from April 14, 2020, to August 31, 2020. All children hospitalized during this time had a SARS-CoV-2 test done as part of standard of care. Postmortem sampling included minimally invasive tissue sampling (MITS) of lung, liver and heart tissue; blood and lung samples for bacterial culture and molecular detection of viruses (including SARS-CoV-2) and bacteria. The cause of death attribution was undertaken by a multidisciplinary team and reported using World Health Organization framework for cause of death attribution. Results: SARS-CoV-2 was identified on antemortem and/or postmortem sampling in 11.7% (20/171) of deceased children, including 13.2% (12/91) in whom MITS was done. Eighteen (90%) of 20 deaths with SARS-CoV-2 infection were <12 months age. COVID-19 was attributed in the causal pathway to death in 91.7% (11/12) and 87.5% (7/8) cases with and without MITS, respectively. Lung histopathologic features in COVID-19-related deaths included diffuse alveolar damage (n = 6, 54.5%), type 2 pneumocyte proliferation (n = 6, 54.5%) and hyaline membrane formation (n = 5, 36.4%). Culture-confirmed invasive bacterial disease was evident in 54.5% (6/11) of COVID-19 attributed deaths investigated with MITS. Conclusions: COVID-19 was in the causal pathway of 10.5% (18/171) of all childhood deaths under surveillance. The postmortem histopathologic features in fatal COVID-19 cases in children were consistent with reports on COVID-19 deaths in adults; although there was a high prevalence of invasive bacterial disease in the children.

引用

页码：E323 / E332

页数：10

共 25 条

[1]

[Anonymous], 2012, The who application of icd-10 to deaths during pregnancy, childbirth and puerperium: icd mm

[2] Validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in Mozambique: An observational study [J].

Bassat, Quique ;

Castillo, Paola ;

Martinez, Miguel J. ;

Jordao, Dercio ;

Lovane, Lucilia ;

Carlos Hurtado, Juan ;

Nhampossa, Tacilta ;

Santos Ritchie, Paula ;

Bandeira, Sonia ;

Sambo, Calvino ;

Chicamba, Valeria ;

Ismail, Mamudo R. ;

Carrilho, Carla ;

Lorenzoni, Cesaltina ;

Fernandes, Fabiola ;

Cistero, Pau ;

Mayor, Alfredo ;

Cossa, Anelsio ;

Mandomando, Inacio ;

Navarro, Mireia ;

Casas, Isaac ;

Vila, Jordi ;

Munguambe, Khatia ;

Maixenchs, Maria ;

Sanz, Ariadna ;

Quinto, Llorenc ;

Macete, Eusebio ;

Alonso, Pedro ;

Menendez, Clara ;

Ordi, Jaume .

PLOS MEDICINE, 2017, 14 (06)

[3] Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study [J].

Bi, Qifang ;

Wu, Yongsheng ;

Mei, Shujiang ;

Ye, Chenfei ;

Zou, Xuan ;

Zhang, Zhen ;

Liu, Xiaojian ;

Wei, Lan ;

Truelove, Shaun A. ;

Zhang, Tong ;

Gao, Wei ;

Cheng, Cong ;

Tang, Xiujuan ;

Wu, Xiaoliang ;

Wu, Yu ;

Sun, Binbin ;

Huang, Suli ;

Sun, Yu ;

Zhang, Juncen ;

Ma, Ting ;

Lessler, Justin ;

Feng, Tiejian .

LANCET INFECTIOUS DISEASES, 2020, 20 (08) :911-919

[4] SARS-CoV-2-Associated Deaths Among Persons Aged <21 Years - United States, February 12-July 31, 2020 [J].

Bixler, Danae ;

Miller, Allison D. ;

Mattison, Claire P. ;

Taylor, Burnestine ;

Komatsu, Kenneth ;

Pompa, Xandy Peterson ;

Moon, Steve ;

Karmarkar, Ellora ;

Liu, Caterina Y. ;

Openshaw, John J. ;

Plotzker, Rosalyn E. ;

Rosen, Hilary E. ;

Alden, Nisha ;

Kawasaki, Breanna ;

Siniscalchi, Alan ;

Leapley, Andrea ;

Drenzek, Cherie ;

Tobin-D'Angelo, Melissa ;

Kauerauf, Judy ;

Reid, Heather ;

Hawkins, Eric ;

White, Kelly ;

Ahmed, Farah ;

Hand, Julie ;

Richardson, Gillian ;

Sokol, Theresa ;

Eckel, Seth ;

Collins, Jim ;

Holzbauer, Stacy ;

Kollmann, Leslie ;

Larson, Linnea ;

Schiffman, Elizabeth ;

Kittle, Theresa S. ;

Herrin, Kimberly ;

Kraushaar, Vit ;

Raman, Devin ;

LeGarde, Victoria ;

Kinsinger, Lindsey ;

Peek-Bullock, Melissa ;

Lifshitz, Jenna ;

Ojo, Mojisola ;

Arciuolo, Robert J. ;

Davidson, Alexander ;

Huynh, Mary ;

Lash, Maura K. ;

Latash, Julia ;

Lee, Ellen H. ;

Li, Lan ;

McGibbon, Emily ;

McIntosh-Beckles, Natasha .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (37) :1324-1329

[5] The COVID-19 crisis in South Africa: Protecting the vulnerable [J].

Blumberg, Lucille ;

Jassat, Waasila ;

Mendelson, Marc ;

Cohen, Cheryl .

SAMJ SOUTH AFRICAN MEDICAL JOURNAL, 2020, 110 (09) :825-826

[6] Potential of Minimally Invasive Tissue Sampling for Attributing Specific Causes of Childhood Deaths in South Africa: A Pilot, Epidemiological Study [J].

Chawana, Richard ;

Baillie, Vicky ;

Izu, Alane ;

Solomon, Fatima ;

Bassat, Quique ;

Blau, Dianna M. ;

Breiman, Robert F. ;

Hale, Martin ;

Houpt, Eric R. ;

Lala, Sanjay G. ;

Martines, Roosecelis B. ;

Mathunjwa, Azwifarwi ;

Nzenze, Susan ;

Pathirana, Jayani ;

Petersen, Karen L. ;

Raghunathan, Pratima L. ;

Ritter, Jana M. ;

Wadula, Jeannette ;

Zaki, Sherif R. ;

Madhi, Shabir A. .

CLINICAL INFECTIOUS DISEASES, 2019, 69 :S361-S373

[7] Age-dependent effects in the transmission and control of COVID-19 epidemics [J].

Davies, Nicholas G. ;

Klepac, Petra ;

Liu, Yang ;

Prem, Kiesha ;

Jit, Mark ;

Eggo, Rosalind M. .

NATURE MEDICINE, 2020, 26 (08) :1205-+

[8] Histopathological observations in COVID-19: a systematic review [J].

Deshmukh, Vishwajit ;

Motwani, Rohini ;

Kumar, Ashutosh ;

Kumari, Chiman ;

Raza, Khursheed .

JOURNAL OF CLINICAL PATHOLOGY, 2021, 74 (02) :76-83

[9] An interactive web-based dashboard to track COVID-19 in real time [J].

Dong, Ensheng ;

Du, Hongru ;

Gardner, Lauren .

LANCET INFECTIOUS DISEASES, 2020, 20 (05) :533-534

[10] Epidemiology of COVID-19 Among Children in China [J].

Dong, Yuanyuan ;

Mo, Xi ;

Hu, Yabin ;

Qi, Xin ;

Jiang, Fan ;

Jiang, Zhongyi ;

Tong, Shilu .

PEDIATRICS, 2020, 145 (06)

← 1 2 3 →