Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria

被引：1
|
作者：
Fernandes Vieira, Jose Luiz [1 ]
Bardalez Rivera, Juan Gonzalo [1 ]
Pereira de Sena, Luann Wendel [1 ]
Dias Ferreira, Michelle Valeria [1 ]
机构：
[1] Para Fed Univ, Pharm Fac, Campus Univ Guama, Belem, Para, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 03期
关键词：
malaria; mefloquine; lipoproteins; lipids; infectious diseases; BINDING; KINETICS; DRUGS; SERUM;
D O I：
10.1128/AAC.01731-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significant associations between the total cholesterol or triglycerides with plasma concentrations of mefloquine and of carboxy-mefloquine. Lipoprotein levels explained 25.68% and 18.31% of mefloquine and carboxy-mefloquine plasma concentrations, respectively.
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页数：4
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