PYK2 and FAK in osteoclasts

被引：24

作者：

Xiong, WC ^{[1
]}

Feng, X ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2003年 / 8卷

关键词：

FAK; PYK2; osteoclasts; integrins; signaling; review;

D O I：

10.2741/1117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integrin alpha(v)beta(3) plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alphavbeta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.

引用

页码：D1219 / D1226

页数：8

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