The role of QSAR in dopamine interactions

被引：11
|
作者：
Hansch, C [1 ]
Verma, RP [1 ]
Kurup, A [1 ]
Mekapati, SB [1 ]
机构：
[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 08期
关键词：
dopamine receptors; QSAR; hydrophobicity; molar refractivity; Verloop's sterimol parameters; hammett parameters;
D O I：
10.1016/j.bmcl.2005.02.012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Dopamine receptor blockers have been used for the treatment of schizophrenia for many years. We have developed 22 quantitative structure activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward dopamine receptors. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2149 / 2157
页数：9
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