Intramolecular oxidative palladium-catalyzed diamination reactions of alkenyl sulfamates: an efficient synthesis of [1,2,5]thiadiazolo-fused piperazinones

被引：6

作者：

Chiacchio, Ugo ^{[1
]}

Broggini, Gianluigi ^{[2
]}

Romeo, Roberto ^{[3
]}

Gazzola, Silvia ^{[2
]}

Chiacchio, Maria A. ^{[1
]}

Giofre, Salvatore V. ^{[3
]}

Gabriele, Bartolo ^{[4
]}

Mancuso, Raffaella ^{[4
]}

Floresta, Giuseppe ^{[1
]}

Zagni, Chiara ^{[1
]}

机构：

[1] Univ Catania, Dipartimento Sci Farm, Viale A Doria 6, I-9515 Catania, Italy

[2] Univ Insubria, Dipartimento Sci & Alta Tecnol, Via Valleggio 9, I-22100 Como, Italy

[3] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Via SS Annunziata, I-98168 Messina, Italy

[4] Univ Calabria, LISOC, Dipartimento Chim & Tecnol Chim, Via B Pucci 12-C, I-87036 Arcavacata Di Rende, CS, Italy

来源：

RSC ADVANCES | 2016年 / 6卷 / 62期

关键词：

N BOND FORMATION; C-N; BIOLOGICAL EVALUATION; UNACTIVATED ALKENES; ALLYLIC ALCOHOLS; DOMINO REACTIONS; VINYL ETHERS; CYCLIZATION; ACID; INHIBITORS;

D O I：

10.1039/c6ra13141g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed diamination domino process of sulfamates arising from glycine allylamides is reported. The reaction leads to the formation of [1,2,5]thiadiazolo-fused piperazinones. The essential feature of the synthetic route is the use of PdCl2(MeCN)(2)/CuBr2, as a catalytic system which promotes the second amination process, leading to the bicycle ring-fused compounds in good yields.

引用

收藏

页码：S7521 / S7529

页数：9

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