Synthesis of Imidazoles and Oxazoles via a Palladium-Catalyzed Decarboxylative Addition/Cyclization Reaction Sequence of Aromatic Carboxylic Acids with Functionalized Aliphatic Nitriles

被引：20

作者：

Dai, Ling ^{[1
]}

Yu, Shuling ^{[1
]}

Lv, Ningning ^{[1
]}

Ye, Xuanzeng ^{[1
]}

Shao, Yinlin ^{[1
]}

Chen, Zhongyan ^{[1
]}

Chen, Jiuxi ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 15期

关键词：

C-H ACTIVATION; COUPLING REACTIONS; BENZOIC-ACIDS; ARYLATION; STRATEGY; PALLADATION; ACCESS; ARENES;

D O I：

10.1021/acs.orglett.1c01762

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report an efficient approach for the assembly of multiply substituted imidazoles and oxazoles in a single-step manner. These transformations are based on a decarboxylation addition and annulation of readily accessible aromatic carboxylic acids and aliphatic nitriles and exhibit good functional group compatibility and a high step economy. The reaction is scalable, and asprepared products could be transformed into practical skeletons. Importantly, the late-stage derivatization of Momelotinib highlights the potential utility of this methodology.

引用

页码：5664 / 5668

页数：5

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