N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses

被引：3
作者：
Feng, Qianyu [1 ,2 ]
Zhao, Hongwei [1 ,2 ]
Xu, Lili [1 ,2 ]
Xie, Zhengde [1 ,2 ]
机构：
[1] Capital Med Univ, Beijing Childrens Hosp,Beijing Key Lab Paediat Re, Natl Ctr Childrens Hlth Beijing Paediat Res Inst, Natl Clin Res Ctr Resp Dis,Natl Key Discipline Pa, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Res Unit Crit Infect Children, Beijing, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
关键词：
N6-methyladenosine; RNA modification; respiratory syncytial virus; adenovirus; human metapneumovirus; influenza A virus; MESSENGER-RNA; NUCLEAR-RNA; M(6)A RNA; STRUCTURAL BASIS; METHYLATION; TRANSLATION; TRANSCRIPTS; PROTEINS; BINDING; YTHDC2;
D O I：
10.3389/fcell.2021.699997
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
N6-methyladenosine (m(6)A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m(6)A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m(6)A in virus-host interactions have shown that m(6)A plays a wide range of regulatory roles in the life cycle of viruses. Respiratory viruses are common pathogens that can impose a large disease burden on young children and elderly people. Here, we review the effects of m(6)A modification on respiratory virus replication and life cycle and host immunity against viruses.
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页数：6
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