Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation

被引:342
作者
Strober, W [1 ]
Kelsall, B [1 ]
Fuss, I [1 ]
Marth, T [1 ]
Ludviksson, B [1 ]
Ehrhardt, R [1 ]
Neurath, M [1 ]
机构
[1] UNIV MAINZ,MED KLIN 1,D-55516 MAINZ,GERMANY
来源
IMMUNOLOGY TODAY | 1997年 / 18卷 / 02期
关键词
D O I
10.1016/S0167-5699(97)01000-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent studies of oral tolerance and experimental colitis indicate that the occurrence of gastrointestinal inflammation is determined by a balance between proinflammatory interferon gamma responses and anti-inflammatory transforming growth factor beta responses. Here, Warren Strober and colleagues discuss the new findings.
引用
收藏
页码:61 / 64
页数:4
相关论文
共 11 条
[1]   Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance [J].
Chen, YHH ;
Weiner, HL .
ORAL TOLERANCE: MECHANISMS AND APPLICATIONS, 1996, 778 :111-121
[2]   INDUCTION OF ANERGY OR ACTIVE SUPPRESSION FOLLOWING ORAL TOLERANCE IS DETERMINED BY ANTIGEN DOSAGE [J].
FRIEDMAN, A ;
WEINER, HL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6688-6692
[3]  
Fuss IJ, 1996, J IMMUNOL, V157, P1261
[4]  
KELSALL BL, 1994, FASEB J, V8, pA207
[5]  
Marth T, 1996, J IMMUNOL, V157, P2348
[6]   ANTIBODIES TO INTERLEUKIN-12 ABROGATE ESTABLISHED EXPERIMENTAL COLITIS IN MICE [J].
NEURATH, MF ;
FUSS, I ;
KELSALL, BL ;
STUBER, E ;
STROBER, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (05) :1281-1290
[7]   Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance [J].
Neurath, MF ;
Fuss, I ;
Kelsall, BL ;
Presky, DH ;
Waegell, W ;
Strober, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) :2605-2616
[8]  
Neurath MF, 1996, GASTROENTEROLOGY, V110, pA979
[9]   INHIBITION OF TH1 RESPONSES PREVENTS INFLAMMATORY BOWEL-DISEASE IN SCID MICE RECONSTITUTED WITH CD45RB(HI) CD4(+) T-CELLS [J].
POWRIE, F ;
LEACH, MW ;
MAUZE, S ;
MENON, S ;
CADDLE, LB ;
COFFMAN, RL .
IMMUNITY, 1994, 1 (07) :553-562
[10]   A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4(+) T cells [J].
Powrie, F ;
Carlino, J ;
Leach, MW ;
Mauze, S ;
Coffman, RL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) :2669-2674