Iron Oxide Monocrystalline Nanoflowers for Highly Efficient Magnetic Hyperthermia

被引:232
作者
Hugounenq, Pierre [2 ]
Levy, Michael [1 ]
Alloyeau, Damien [3 ]
Lartigue, Lenaic [1 ]
Dubois, Emmanuelle [2 ]
Cabuil, Valerie [2 ]
Ricolleau, Christian [3 ]
Roux, Stephane [4 ]
Wilhelm, Claire [1 ]
Gazeau, Florence [1 ]
Bazzi, Rana [2 ,4 ]
机构
[1] Univ Paris Diderot, Lab Matiere & Syst Complexes, UMR 7057, CNRS, F-75205 Paris 13, France
[2] Univ Paris 06, CNRS, Lab Physicochim Electrolytes Colloides & Chim Ana, UMR 7195,ESPCI, F-75252 Paris 05, France
[3] Univ Paris Diderot, Lab Mat & Phenomenes Quant, UMR 7162, CNRS, F-75205 Paris 13, France
[4] Univ Franche Comte, Inst UTINAM, UMR 6213, CNRS, F-25030 Besancon, France
关键词
BACTERIAL MAGNETOSOMES; FERRITE NANOPARTICLES; PARTICLES; RESONANCE; CONTRAST; DESIGN; FLUIDS;
D O I
10.1021/jp3025478
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Magnetic nanoparticles exhibit a high potential to selectively treat cancer by hyperthermia provided that high heating capacity can be reached. In this work, we report an efficient synthesis of novel structures of magnetic iron oxide. The particles, obtained by applying a modified "polyol" protocol, present a particular shape: they look constituted of smaller grains of approximately 11 nm, assembled in a flower-shaped structure. These nanoflowers, dispersed in water at physiological pH, present particularly interesting magnetic properties and a great capacity of heating. The value of the specific loss power (SLP) of these nanoflowers is 1 order of magnitude higher than the SLP reported for conventional single-domain maghemite nanoparticles in the same condition of field exposure.
引用
收藏
页码:15702 / 15712
页数:11
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