Cardiac QTc interval characteristics before and after hematopoietic stem cell transplantation: an analysis of 995 consecutive patients at a single center

被引:6
作者
Miller, W. P. [1 ]
Shanley, R. [2 ]
Dorostkar, P. [3 ]
机构
[1] Univ Minnesota, Div Blood & Marrow Transplantat, Dept Pediat, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Mason Canc Ctr, Biostat Core, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Div Pediat Cardiol, Minneapolis, MN 55455 USA
基金
美国国家卫生研究院;
关键词
PREDICTIVE-VALUE; PROLONGATION; CHEMOTHERAPY; PARAMETERS; DISPERSION; THERAPY; FAILURE;
D O I
10.1038/bmt.2015.64
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Hematopoietic stem cell transplantation (HSCT) treats disorders affecting patients of all ages. We studied the rate-corrected cardiac QT interval (QTc) in 995 consecutive children and adults undergoing HSCT at the University of Minnesota. We sought to (1) describe QTc before and after HSCT; (2) describe the change in QTc after HSCT; (3) identify factors affecting QTc and its change; and (4) scrutinize an 'at risk' sub-cohort with a long QTc before HSCT. Pre HSCT: 952 (96%) patients had an evaluable electrocardiography (ECG); median QTc was 426 ms and depended upon disease necessitating transplant. Post HSCT: 506 (51%) patients had an evaluable ECG; median QTc was 441 ms. Intrapatient QTc change: 490 (49%) evaluable patients showed median QTc change (pre to post HSCT) of +16 ms (P < 0.0001). At risk group: 68 patients were 'at risk' (long pre-HSCT QTc). In some, 'at-risk' status trended toward predictive of post-transplant nonrelapse mortality. QTc interval prolongation is evident in a large, diverse cohort undergoing HSCT at our institution. Prospective studies of this patient population may be warranted, particularly for 'at-risk' patients who demonstrate significant QTc prolongation both pre and post HSCT.
引用
收藏
页码:954 / 960
页数:7
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