Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia

被引：62

作者：

Niitsu, Tomihisa ^{[2
]}

Shirayama, Yukihiko ^{[1
,2
]}

Matsuzawa, Daisuke ^{[3
]}

Hasegawa, Tadashi ^{[2
]}

Kanahara, Nobuhisa ^{[2
]}

Hashimoto, Tasuku ^{[2
]}

Shiraishi, Tetsuya ^{[2
]}

Shiina, Akihiro ^{[2
]}

Fukami, Goro ^{[2
]}

Fujisaki, Mihisa ^{[2
]}

Watanabe, Hiroyuki ^{[2
]}

Nakazato, Michiko ^{[2
]}

Asano, Makoto ^{[4
]}

Kimura, Sho ^{[5
]}

Hashimoto, Kenji ^{[6
]}

Iyo, Masaomi ^{[2
]}

机构：

[1] Teikyo Univ, Chiba Med Ctr, Dept Psychiat, Ichihara, Chiba 2990111, Japan

[2] Chiba Univ, Grad Sch Med, Dept Psychiat, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Cognit Behav Physiol, Chiba, Japan

[4] Chiba Psychiat Med Ctr, Chiba, Japan

[5] Kimura Hosp, Chiba, Japan

[6] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2011年 / 35卷 / 08期

关键词：

BDNF; Cognitive impairment; Negative symptom; Schizophrenia; LONG-TERM TREATMENT; BDNF LEVELS; ATYPICAL ANTIPSYCHOTICS; NEUROCOGNITIVE DEFICITS; FOLLOW-UP; 1ST-EPISODE; PERFORMANCE; DISORDER; OLANZAPINE; PSYCHOSIS;

D O I：

10.1016/j.pnpbp.2011.09.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. The aim of this study was to examine the associations of serum BDNF levels with the cognition and clinical characteristics in patients with schizophrenia. Sixty-three patients with schizophrenia and 52 age- and sex-matched healthy controls were examined with neuropsychological tests. Serum BDNF levels were determined by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in serum BDNF levels between normal controls and patients with schizophrenia. Serum BDNF levels of normal controls showed negative correlations with verbal working memory, but this was not the case with schizophrenic patients. Meanwhile, serum BDNF levels of schizophrenic patients showed positive correlations with the scores of the Scale for the Assessment of Negative Symptoms (SANS) and the Information subtest scores of Wechsler Adult Intelligence Scale Revised (WAIS-R). Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1836 / 1840

页数：5

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