Functions and clinical applications of exosomes in pancreatic cancer

被引：8
作者：
Jiang, Zhichen [1 ,2 ]
Wang, Huiju [1 ,3 ,4 ]
Mou, Yiping [1 ,3 ,4 ]
Li, Li [1 ,3 ,4 ]
Jin, Weiwei [1 ,3 ,4 ]
机构：
[1] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Devis Gastroenterol & Pancreas, Dept Gen Surg,Hangzhou Med Coll, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Clin Med 2, Hangzhou 310053, Zhejiang, Peoples R China
[3] Key Lab Gastroenterol Zhejiang Prov, Hangzhou 310014, Zhejiang, Peoples R China
[4] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Canc Ctr, Hangzhou 310014, Zhejiang, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 11期
关键词：
Exosome; Extracellular vesicles; Pancreatic cancer; Biomarker; Therapy; DENDRITIC CELLS; EXTRACELLULAR VESICLES; MESSENGER-RNA; STEM-CELLS; EXPRESSION; PROTEINS; CHEMORESISTANCE; FIBROBLASTS; NEUTROPHILS; BIOGENESIS;
D O I：
10.1007/s11033-022-07765-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic cancer (PC) is one of the most malignant tumors and has an abysmal prognosis, with a 5-year survival rate of only 11%. At present, the main clinical dilemmas in PC are the lack of biomarkers and the unsatisfactory therapeutic effects. The treatments for and outcomes of PC have improved, but remain unsatisfactory. Exosomes are nanosized extracellular vesicles, and an increasing number of studies have found that exosomes play an essential role in tumor pathology. In this review, we describe the process of exosome biogenesis, as well as exosome extraction methods and identification strategies, and we then explain in detail the roles and mechanisms of exosomes in invasion, metastasis, chemoresistance and immunosuppression in PC. Finally, we summarize the clinical applications of exosomes. Our observations indicate that exosomes represent a novel direction in the clinical treatment of PC.
引用
收藏
页码：11037 / 11048
页数：12
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