An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

被引：5

作者：

Behera, Manoranjan ^{[1
]}

Ragavan, R. Venkat ^{[1
]}

Sambaiah, M. ^{[1
]}

Erugu, Balaiah ^{[1
]}

Reddy, J. Rama Krishna ^{[1
,2
]}

Mukkanti, K. ^{[2
]}

Yennam, Satyanarayana ^{[1
]}

机构：

[1] GVK Biosci Pvt Ltd, Chem Serv, IDA, Hyderabad 500076, Andhra Pradesh, India

[2] JNT Univ, Div Chem, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 09期

关键词：

Ethyl-1-imidazole carbamate; LiHMDS; Mono-alpha-aryl derivatives of diethyl malonate and ethyl cyanoacetate; CATALYZED ARYLATION; ENANTIOSELECTIVE SYNTHESIS; ACID; ENANTIOMERS; DESYMMETRIZATION; ESTERIFICATION; CONSTRUCTION; AMIDATION; KETONES;

D O I：

10.1016/j.tetlet.2011.12.067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of mono alpha-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC) has been described. Using this method many sterically hindered and highly substituted mono alpha-aryl derivatives of diethyl malonate and ethyl cyanoacetate were synthesized in high yield. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1060 / 1062

页数：3

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