Synthesis, structure, and biological activity of 4-hetaryl-2-pyrrolidones containing a pyrazole ring

被引：2

作者：

Gorodnicheva, Natal'ya V. ^{[1
]}

Vasil'eva, Olga S. ^{[1
]}

Ostroglyadov, Evgeny S. ^{[1
]}

Baichurin, Ruslan I. ^{[1
]}

Litvinov, Igor A. ^{[2
]}

Tyurenkov, Ivan N. ^{[3
]}

Kovalev, Nikolay S. ^{[3
]}

Bakulin, Dmitry A. ^{[3
]}

Kurkin, Denis V. ^{[3
]}

Baichurina, Larisa V. ^{[4
]}

Makarenko, Sergey V. ^{[1
]}

机构：

[1] Herzen State Pedag Univ Russia, 48 Moyka River Embankment, St Petersburg 191186, Russia

[2] AE Arbuzov Inst Organ & Phys Chem, 8 Akademika Arbuzova St, Kazan 420088, Russia

[3] Volgograd State Med Univ, 1 Pavshikh Bortsov Sq, Volgograd 400131, Russia

[4] Kirov Mil Med Acad, 6 Akademika Lebedeva St, St Petersburg 194044, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2022年 / 58卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

carbohydrazides; 3,5-dimethylpyrazole; hydrazides; 2-pyrrolidone; biological activity; racetams; X-ray structural analysis; STEREOSELECTIVE-SYNTHESIS; GAMMA-LACTAMS; ANTIBACTERIAL; PIRACETAM; ACIDS;

D O I：

10.1007/s10593-022-03140-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Single diastereomers of 4-hetaryl-2-pyrrolidone-3(5)-carbo- and 2-[4-hetaryl-2-pyrrolidon-1-yl]acetohydrazides were used in reactions with 2,4-pentanedione, providing (3R*,4S*)-3-, (4R*,5R*)-5-(3,5-dimethyl-1H-pyrazole-1-carbonyl)- and 1-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-2-oxoethyl]-4-hetaryl-2-pyrrolidones. The structures of the synthesized compounds were confirmed by spectral methods and X-ray structural analysis. Some of the obtained compounds were shown to possess nootropic and anxiolytic activity.

引用

页码：598 / 607

页数：10

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