Stem cell therapy for multiple sclerosis: preclinical evidence beyond all doubt?

被引：0

作者：

Reekmans, Kristien ^{[1
]}

Praet, Jelle ^{[1
,2
]}

De Vocht, Nathalie ^{[1
,2
]}

Daans, Jasmijn ^{[1
]}

Van der Linden, Annemie ^{[2
]}

Berneman, Zwi ^{[1
]}

Ponsaerts, Peter ^{[1
]}

机构：

[1] Univ Antwerp VIB, Vaccine & Infect Dis Inst Vaxinfectio, Lab Expt Hematol, B-2610 Antwerp, Belgium

[2] Univ Antwerp VIB, Biolmaging Lab, B-2610 Antwerp, Belgium

来源：

REGENERATIVE MEDICINE | 2012年 / 7卷 / 02期

关键词：

cell migration; cell transplantation; differentiation; experimental autoimmune encephalomyelitis; inflammation; mesenchymal stem cell; multiple sclerosis; neural stem cell; neuroregeneration; trophic support; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NEURAL PRECURSOR CELLS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; T-REGULATORY-CELLS; CENTRAL-NERVOUS-SYSTEM; DENDRITIC CELLS; IN-VIVO; STROMAL CELLS; DISEASE PROGRESSION; IMMUNE-RESPONSE;

D O I：

10.2217/RME.12.5

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cell transplantation holds great promise for restoration of neural function in various neurodegenerative disorders, including multiple sclerosis (MS). However, many questions remain regarding the true efficacy and precise mode of action of stem cell-based therapeutic approaches. Therefore, in this article, we will first discuss the ideal route and/or timing of stem cell-based therapies for experimental autoimmune encephalomyelitis (EAE), the most used preclinical animal model for MS. Next, we will provide an overview of the proposed mechanisms that contribute to the beneficial effects of stem cell transplantation observed during the treatment of rodent EAE. Reviews of current and past literature clearly demonstrate conceptual changes in the development of stem cell-based approaches for EAE/MS, leading to the identification of several major challenges to be tackled before (stem) cell therapy for rodent EAE can be safely and successfully translated to human therapy for MS.

引用

页码：245 / 259

页数：15

共 93 条

[1] Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in Experimental Autoimmune Encephalomyelitis [J].