Using Protein Interaction Networks to Understand Complex Diseases

被引：7
作者：
Koyutuerk, Mehmet [1 ]
机构：
[1] Case Western Reserve Univ, Cleveland, OH 44106 USA
来源：
COMPUTER | 2012年 / 45卷 / 03期
基金：
美国国家科学基金会;
关键词：
Biotechnology; Proteins; Gene expression; Bioinformatics; Genomics; Biological system modeling; Biological cells; Biomedical informatics; Information theory; information theory; computational biology; genetics; bioinformatics; databases; mining methods and algorithms; graph algorithms; CANCER; PATHWAYS; OPINION;
D O I：
10.1109/MC.2012.40
中图分类号：
TP3 [计算技术、计算机技术];
学科分类号：
0812 ;
摘要：
Recent developments in biotechnology have enabled interrogation of the cell at various levels, leading to many types of "omic" data that provide valuable information on multiple genetic and environmental factors and their interactions.
引用
收藏
页码：31 / 38
页数：8
相关论文
共 28 条
[1]   Computational analysis of the synergy among multiple interacting genes [J].
Anastassiou, Dimitris .
MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)
[2]  
Chowdhury S.A., 2010, P PAC S BIOC
[3]   Subnetwork State Functions Define Dysregulated Subnetworks in Cancer [J].
Chowdhury, Salim A. ;
Nibbe, Rod K. ;
Chance, Mark R. ;
Koyutuerk, Mehmet .
JOURNAL OF COMPUTATIONAL BIOLOGY, 2011, 18 (03) :263-281
[4]   Network-based classification of breast cancer metastasis [J].
Chuang, Han-Yu ;
Lee, Eunjung ;
Liu, Yu-Tsueng ;
Lee, Doheon ;
Ideker, Trey .
MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)
[5]   Optimally discriminative subnetwork markers predict response to chemotherapy [J].
Dao, Phuong ;
Wang, Kendric ;
Collins, Colin ;
Ester, Martin ;
Lapuk, Anna ;
Sahinalp, S. Cenk .
BIOINFORMATICS, 2011, 27 (13) :I205-I213
[6]   Inferring cancer subnetwork markers using density-constrained biclustering [J].
Dao, Phuong ;
Colak, Recep ;
Salari, Raheleh ;
Moser, Flavia ;
Davicioni, Elai ;
Schoenhuth, Alexander ;
Ester, Martin .
BIOINFORMATICS, 2010, 26 (18) :i625-i631
[7]   Protein Networks as Logic Functions in Development and Cancer [J].
Dutkowski, Janusz ;
Ideker, Trey .
PLOS COMPUTATIONAL BIOLOGY, 2011, 7 (09)
[8]   VIEWPOINT Missing heritability and strategies for finding the underlying causes of complex disease [J].
Eichler, Evan E. ;
Flint, Jonathan ;
Gibson, Greg ;
Kong, Augustine ;
Leal, Suzanne M. ;
Moore, Jason H. ;
Nadeau, Joseph H. .
NATURE REVIEWS GENETICS, 2010, 11 (06) :446-450
[9]   Decanalization and the origin of complex disease [J].
Gibson, Greg .
NATURE REVIEWS GENETICS, 2009, 10 (02) :134-140
[10]   Differential analysis of DNA microarray gene expression data [J].
Hatfield, GW ;
Hung, SP ;
Baldi, P .
MOLECULAR MICROBIOLOGY, 2003, 47 (04) :871-877
123