High-level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112

被引：92

作者：

Santos, Filipe ^{[1
,2
]}

Wegkamp, Arno ^{[1
,2
]}

de Vos, Willem M. ^{[3
]}

Smid, Eddy J. ^{[1
,2
]}

Hugenholtz, Jeroen ^{[1
,2
]}

机构：

[1] NIZO Food Res, NL-6710 BA Ede, Netherlands

[2] TI Food & Nut, Kluyver Ctr Genom Ind Fermentat, NL-6710 BA Ede, Netherlands

[3] Univ Wageningen & Res Ctr, Microbiol Lab, NL-6703 HB Wageningen, Netherlands

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2008年 / 74卷 / 10期

关键词：

D O I：

10.1128/AEM.02719-07

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We observed that Lactobacillus reuteri JCM1112 produces B-12 and folate. However, the folate/1112 mass ratio found was far below that desired for human consumption (similar to 170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.

引用

页码：3291 / 3294

页数：4

共 30 条

[1] 2 GLOBAL REGULATORY SYSTEMS (CRP AND ARC) CONTROL THE COBALAMIN PROPANEDIOL REGULON OF SALMONELLA-TYPHIMURIUM [J].

AILION, M ;

BOBIK, TA ;

ROTH, JR .

JOURNAL OF BACTERIOLOGY, 1993, 175 (22) :7200-7208

[2]

ALTSCHUL SF, 1997, NUCLEIC ACIDS RES, V25, P3402

[3]

[Anonymous], 2004, VIT MIN REQ HUM NUTR

[4]

[Anonymous], THESIS WAGENINGEN U

[5]

Carmel Ralph, 2003, Hematology Am Soc Hematol Educ Program, P62

[6]

de Vos WM, 1999, INT DAIRY J, V9, P3, DOI 10.1016/S0958-6946(99)00038-2

[7]

*FAO WHO, 2005, 4 SESS FAO COMM COMM

[8]

HORNE DW, 1988, CLIN CHEM, V34, P2357

[9]

Horowitz W., 2006, Official methods of analysis of AOAC International, V18th

[10]

Kandler O., 1986, BERGEYS MANUAL SYSTE, V2, P1208

← 1 2 3 →