Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives

被引：76
作者：
Yi, Yu [1 ,2 ,3 ]
Lin, Gan [4 ]
Chen, Shaoyi [1 ,2 ]
Liu, Jing [1 ,2 ]
Zhang, Huaping [1 ,2 ]
Mi, Peng [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Ctr Med Imaging,Dept Radiol, 17,3rd Sect,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, State Key Lab Biotherapy, 17,3rd Sect,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China
[3] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan
[4] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2018年 / 83卷
关键词：
Polyester; Micelle; Cancer therapy; Drug delivery systems; Theranostics; BLOCK-COPOLYMER MICELLES; PLGA-BASED NANOPARTICLES; PEG-PLA NANOPARTICLES; POLYMERIC MICELLES; IN-VIVO; BIOMEDICAL APPLICATIONS; UNIMOLECULAR MICELLES; RESPONSIVE NANOPARTICLES; TARGETED NANOPARTICLES; BIODEGRADABLE POLYMERS;
D O I：
10.1016/j.msec.2017.10.004
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The development of tumor-targeting nanocarriers is critical important for effective treatment. The synthetic polyesters have demonstrated high potential for developing nanocarriers for cancer theranostics. Especially, the biocompatible and biodegradable polyester micelles have held great promise for cancer therapy and diagnosis, while some candidates have been translated into clinical applications or under clinical trial. In this review, we have provided the state-of-the-art of polyester micelles for drug delivery and cancer theranostics. In addition, we have summarized several major types of polyesters used in the biomedical fields, the current clinical achievements of polyester micelles and recent progresses of multi-functional polyester micelles for tumor molecular imaging and therapeutic applications.
引用
收藏
页码：218 / 232
页数：15
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