Indication of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer (Gastripec, Gastrichip)

被引：6

作者：

Rau, Beate ^{[1
,2
,3
,4
]}

Feldbruegge, Linda ^{[1
,2
,3
,4
]}

Gronau, Felix ^{[1
,2
,3
,4
]}

Vilchez, Miguel Enrique Alberto ^{[1
,2
,3
,4
]}

Thuss-Patience, Peter ^{[5
,6
,7
,8
]}

Bonnot, Pierre Emmanuel ^{[9
,10
]}

Glehen, Olivier ^{[10
]}

机构：

[1] Charite, Dept Surg, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Charite, Chirurg Klin Campus Charite Mitte Campus Vircho, Berlin Inst Hlth, Berlin, Germany

[5] Charite, Med Klin Schwerpunkt Hamatol, Onkol & Tumour Immunol Campus Virchow Klin, Berlin, Germany

[6] Free Univ Berlin, Berlin, Germany

[7] Humboldt Univ, Berlin, Germany

[8] Charite, Berlin Inst Hlth, Berlin, Germany

[9] Hop Prive Jean Mermoz, Dept Gen, Visceral & oncol Surg, Lyon, France

[10] Hosp Civils Lyon, Dept Surg Oncol, CHU Lyon Sud, Lyon, France

来源：

VISCERAL MEDICINE | 2022年 / 38卷 / 02期

关键词：

Peritoneal metastasis; Gastric cancer; Prophylactic hyperthermic intraperitoneal chemotherapy; Hyperthermic intraperitoneal chemotherapy; Peritonectomy; PERITONEAL CARCINOMATOSIS; CYTOREDUCTIVE SURGERY; STAGING LAPAROSCOPY; PERIOPERATIVE CHEMOTHERAPY; LAVAGE CYTOLOGY; OPEN-LABEL; MULTICENTER; ADENOCARCINOMA; HIPEC; RECURRENCE;

D O I：

10.1159/000522604

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Gastric cancer (GC) is associated with a poor prognosis mostly due to peritoneal metastasis, which will develop in time during the patient's disease history. To prevent and treat peritoneal metastasis, different kinds of treatment regimens have been described. Summary: In this review, we addressed two main topics - prophylaxis and treatment of peritoneal metastasis in GC. Prevention should be directed towards diminishing cancer cell spillage and reducing adherence of cancer cells to the abdominal cavity. Postoperative washing of the abdomen with or without chemotherapy and additional heat are herein discussed. Key Messages: Treatment of existing peritoneal metastasis is effective in patients with limited disease and tumour spread. Cytoreductive surgery including resection of peritoneal metastasis followed directly with hyperthermic intraperitoneal chemotherapy can increase overall survival and progression-free survival in selected patients. Drugs, duration and time schedules of intraperitoneal chemotherapy are reviewed and presented. Intraperitoneal chemotherapy seems to improve the prognosis of patients with GC and peritoneal metastasis after complete resection of both primary and metastatic tumours.

引用

页码：81 / 89

页数：9

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