Cananginone Abrogates EMT in Breast Cancer Cells through Hedgehog Signaling

被引：11

作者：

Bose, Chandra ^{[1
]}

Das, Ujjal ^{[1
]}

Kuilya, Tapan Kumar ^{[2
]}

Mondal, Joyanta ^{[2
]}

Bhadra, Jhuma ^{[1
]}

Banerjee, Priyanjalee ^{[1
]}

Goswami, Rajib Kumar ^{[2
]}

Sinha, Surajit ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Sch Appl & Interdisciplinary Sci, Kolkata 700032, India

[2] Indian Assoc Cultivat Sci, Sch Chem Sci, Kolkata 700032, India

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 05期

关键词：

natural product; cananginone; epithelial to mesenchymal transition (EMT); hedgehog; breast cancer; INDOLE HYBRID MOLECULE; PATHWAY; ACETOGENINS; INHIBITION; STRATEGIES; GLI1;

D O I：

10.1002/cbdv.202100823

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cananginones, a family of linear acetogenins found as secondary metabolites in the plant kingdom, show cytotoxicity against several types of cancer cells. We aimed to investigate the efficacy of cananginone and its mechanism as an anti-cancer agent. Our initial screening of Cananginone against HepG2, PC3, A549, and MCF7 cells showed anti-cancer activities and is more potent against MCF7 cells, consistent with the previous report. Next, cell-based assays have revealed that cananginone abrogates cancer stem cell renewal as well as Epithelial-Mesenchymal Transition (EMT) and increased the ROS level beyond the threshold level thus reducing the viability of cancer cells. In the connection of Hh-Gli to EMT, our study indicated that cananginone inhibits Gli1 in a non-canonical pathway. Presumably, this is the first report on the inhibitory activity of cananginone in the Hh pathway and is different from Hh-antagonists cyclopamine and GANT 61 considering the mechanism.

引用

页数：12

共 50 条

[21] Hedgehog signaling in mammary gland development and breast cancer
Hatsell, Sarah
Frost, Andra R.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2007, 12 (2-3) : 163 - 173
[22] Expression of Indian Hedgehog signaling molecules in breast cancer
Xuan, Yanhua
Lin, Zhenhua
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2009, 135 (02) : 235 - 240
[23] Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
Riobo-Del Galdo, Natalia A.
Lara Montero, Angela
Wertheimer, Eva V.
CELLS, 2019, 8 (04)
[24] Hedgehog Signaling in the Maintenance of Cancer Stem Cells
Cochrane, Catherine R.
Szczepny, Anette
Watkins, D. Neil
Cain, Jason E.
CANCERS, 2015, 7 (03): : 1554 - 1585
[25] Interaction of Hedgehog-Gli and estrogen receptor signaling pathways in breast cancer cells
Levanat, S.
Trnski, D.
Uzarevic, Z.
Ozretic, P.
Musani, V.
Sabol, M.
EUROPEAN JOURNAL OF CANCER, 2014, 50 : S118 - S118
[26] Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling
Villegas, Victoria E.
Rondon-Lagos, Milena
Annaratone, Laura
Castellano, Isabella
Grismaldo, Adriana
Sapino, Anna
Zaphiropoulos, Peter G.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (03)
[27] Molecular imaging of the hedgehog signaling pathway in breast cancer
Smith, D. L.
Larson, R.
Kong, F.
Yang, D.
Woodward, W.
Sims-Mourtada, J.
JOURNAL OF NUCLEAR MEDICINE, 2013, 54 : 23 - 23
[28] Hedgehog signaling pathway as a therapeutic target in breast cancer
Katano, M
CANCER LETTERS, 2005, 227 (02) : 99 - 104
[29] microRNAs and EMT in Mammary Cells and Breast Cancer
Wright, Josephine A.
Richer, Jennifer K.
Goodall, Gregory J.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2010, 15 (02) : 213 - 223
[30] Sulforaphene inhibited migration through down-regulating the Hedgehog signaling in SUM159 human breast cancer cells
Bao, Cheng
Lee, Jaehoo
Ko, Jiwon
Park, Hyun-Chang
Lee, Hong Jin
CANCER RESEARCH, 2014, 74 (19)

← 1 2 3 4 5 →