DNA replication origin activation in space and time

被引：369

作者：

Fragkos, Michalis ^{[1
]}

Ganier, Olivier ^{[1
]}

Coulombe, Philippe ^{[1
]}

Mechali, Marcel ^{[1
]}

机构：

[1] CNRS, Inst Human Genet, F-34396 Montpellier, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2015年 / 16卷 / 06期

基金：

欧洲研究理事会;

关键词：

S-PHASE CHECKPOINT; CDK-DEPENDENT PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; GENOME-WIDE; RECOGNITION COMPLEX; CELL-CYCLE; TRANSCRIPTION FACTORS; SUBCELLULAR LOCATION; MEDIATED PROTEOLYSIS; INITIATION EVENTS;

D O I：

10.1038/nrm4002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1-S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis. However, only a subset of origins are activated during any S phase. Recent insights into the mechanisms underlying this choice reveal how flexibility in origin usage and temporal activation are linked to chromosome structure and organization, cell growth and differentiation, and replication stress.

引用

页码：360 / 374

页数：15

共 192 条

[1] Genomic Instability in Cancer [J].

Abbas, Tarek ;

Keaton, Mignon A. ;

Dutta, Anindya .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2013, 5 (03)

[2] Chromatin regulates origin activity in Drosophila follicle cells [J].

Aggarwal, BD ;

Calvi, BR .

NATURE, 2004, 430 (6997) :372-376

[3] THE SAD1/RAD53 PROTEIN-KINASE CONTROLS MULTIPLE CHECKPOINTS AND DNA DAMAGE-INDUCED TRANSCRIPTION IN YEAST [J].

ALLEN, JB ;

ZHOU, Z ;

SIEDE, W ;

FRIEDBERG, EC ;

ELLEDGE, SJ .

GENES & DEVELOPMENT, 1994, 8 (20) :2401-2415

[4] Dynamics of DNA replication in mammalian somatic cells: Nucleotide pool modulates origin choice and interorigin spacing [J].

Anglana, M ;

Apiou, F ;

Bensimon, A ;

Debatisse, M .

CELL, 2003, 114 (03) :385-394

[5] PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication [J].

Arias, EE ;

Walter, JC .

NATURE CELL BIOLOGY, 2006, 8 (01) :84-U33

[6] Identification of Early Replicating Fragile Sites that Contribute to Genome Instability [J].

Barlow, Jacqueline H. ;

Faryabi, Robert B. ;

Callen, Elsa ;

Wong, Nancy ;

Malhowski, Amy ;

Chen, Hua Tang ;

Gutierrez-Cruz, Gustavo ;

Sun, Hong-Wei ;

McKinnon, Peter ;

Wright, George ;

Casellas, Rafael ;

Robbiani, Davide F. ;

Staudt, Louis ;

Fernandez-Capetillo, Oscar ;

Nussenzweig, Andre .

CELL, 2013, 152 (03) :620-632

[7] Checking on DNA damage in S phase [J].

Bartek, J ;

Lukas, C ;

Lukas, J .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (10) :792-804

[8] The role of PR-Set7 in replication licensing depends on Suv4-20h [J].

Beck, David B. ;

Burton, Adam ;

Oda, Hisanobu ;

Ziegler-Birling, Celine ;

Torres-Padilla, Maria-Elena ;

Reinberg, Danny .

GENES & DEVELOPMENT, 2012, 26 (23) :2580-2589

[9] NCOA4 Transcriptional Coactivator Inhibits Activation of DNA Replication Origins [J].

Bellelli, Roberto ;

Castellone, Maria Domenica ;

Guida, Teresa ;

Limongello, Roberto ;

Dathan, Nina Alayne ;

Merolla, Francesco ;

Cirafici, Anna Maria ;

Affuso, Andrea ;

Masai, Hisao ;

Costanzo, Vincenzo ;

Grieco, Domenico ;

Fusco, Alfredo ;

Santoro, Massimo ;

Carlomagno, Francesca .

MOLECULAR CELL, 2014, 55 (01) :123-137

[10] Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-Wide Analysis of Chromatin Structure [J].

Berbenetz, Nicolas M. ;

Nislow, Corey ;

Brown, Grant W. .

PLOS GENETICS, 2010, 6 (09)

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