Hyperbranched poly(L-lysine) modified with histidine residues via lysine terminal amino groups:: Synthesis and structure

被引：4

作者：

Vlasov, G. P. ^{[1
]}

Filippov, A. P. ^{[1
]}

Tarasenko, I. I. ^{[1
]}

Tarabukina, E. B. ^{[1
]}

Pankova, G. A. ^{[1
]}

Il'ina, I. E. ^{[1
]}

Shpyrkov, A. A. ^{[1
]}

Skvortsova, E. V. ^{[2
]}

Skvortsov, A. I. ^{[1
]}

Vorob'ev, V. I. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia

[2] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia

来源：

POLYMER SCIENCE SERIES A | 2008年 / 50卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1134/S0965545X08040032

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A method for preparing hyperbranched poly(L-lysine) via the polymerization of N-epsilon-carbobenzoxy-L-lysine-N-carboxyanhydride has been developed in order to regulate the molecular mass and size of this polymer and to modify amino groups of its N-terminal lysine residues. This method includes the reductive removal of an N-epsilon-carbobenzoxy group by hydrogen over activated palladium in the presence of a chain termination agent, which is the activated ether of N-alpha-tert-butyloxycarbonylhistidine. The structure of the polymers has been studied by capillary electrophoresis, circular dichroism, and molecular hydrodynamics.

引用

页码：374 / 381

页数：8

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