Hyperbranched poly(L-lysine) modified with histidine residues via lysine terminal amino groups:: Synthesis and structure

被引：4
|
作者：
Vlasov, G. P. [1 ]
Filippov, A. P. [1 ]
Tarasenko, I. I. [1 ]
Tarabukina, E. B. [1 ]
Pankova, G. A. [1 ]
Il'ina, I. E. [1 ]
Shpyrkov, A. A. [1 ]
Skvortsova, E. V. [2 ]
Skvortsov, A. I. [1 ]
Vorob'ev, V. I. [2 ]
机构：
[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia
[2] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia
来源：
POLYMER SCIENCE SERIES A | 2008年 / 50卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1134/S0965545X08040032
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A method for preparing hyperbranched poly(L-lysine) via the polymerization of N-epsilon-carbobenzoxy-L-lysine-N-carboxyanhydride has been developed in order to regulate the molecular mass and size of this polymer and to modify amino groups of its N-terminal lysine residues. This method includes the reductive removal of an N-epsilon-carbobenzoxy group by hydrogen over activated palladium in the presence of a chain termination agent, which is the activated ether of N-alpha-tert-butyloxycarbonylhistidine. The structure of the polymers has been studied by capillary electrophoresis, circular dichroism, and molecular hydrodynamics.
引用
收藏
页码：374 / 381
页数：8
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