Snail Mucus Enhances Chemosensitivity of Triple-negative Breast Cancer Via Activation of the Fas Pathway

被引：6

作者：

Ho, Chien-Yi ^{[1
,2
,3
,4
]}

Hu, Dai-Wei ^{[5
,6
]}

Chen, Bo-Rong ^{[5
,6
,7
,8
]}

Yang, Chun-Chun ^{[8
]}

Yao, Chun-Hsu ^{[1
,9
,10
]}

Ni, Tien ^{[11
,12
]}

Ho, Wei-Chuan ^{[1
,2
,3
,4
]}

Chen, Yueh-Sheng ^{[1
,9
,10
]}

Tu, Chih-Yen ^{[7
,13
]}

Chang, Wei-Chao ^{[6
]}

Wu, Yang-Chang ^{[14
,15
,16
]}

Tang, Chih-Hsin ^{[5
,7
]}

Huang, Hui-Chi ^{[17
]}

Huang, Wei-Chien ^{[5
,6
,18
,19
]}

Li, Tzong-Shiun ^{[20
,21
]}

机构：

[1] China Med Univ, Dept Biomed Imaging & Radiol Sci, Taichung, Taiwan

[2] China Med Univ, Div Family Med, Hsinchu Hosp, Hsinchu, Taiwan

[3] China Med Univ, Phys Examinat Ctr, Hsinchu Hosp, Hsinchu, Taiwan

[4] China Med Univ, Dept Med Res, Hsinchu Hosp, Hsinchu, Taiwan

[5] China Med Univ, Grad Inst Biomed Sci, 6 Xueshi Rd, Taichung, Taiwan

[6] China Med Univ Hosp, Ctr Mol Med, Taichung, Taiwan

[7] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan

[8] Natl Taichung First Senior High Sch, Taichung, Taiwan

[9] China Med Univ Hosp, Biomat Translat Res Ctr, Dept Med Res, Taichung, Taiwan

[10] Asia Univ, Coll Med & Hlth Sci, Dept Bioinformat & Med Engn, Dept Psychol, Taichung, Taiwan

[11] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan

[12] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan

[13] China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Taichung, Taiwan

[14] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung, Taiwan

[15] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung, Taiwan

[16] Asia Univ, Coll Med & Hlth Sci, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan

[17] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, 91 Hsueh Shih Rd, Taichung, Taiwan

[18] China Med Univ, Drug Dev Ctr, Taichung, Taiwan

[19] Asia Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan

[20] Show Chwan Mem Hosp, Dept Plast Surg, 542,Sect 1,Zhongshan Rd, Changhua, Taiwan

[21] Show Chwan Hlth Care Syst, Innovat Res Ctr, Changhua, Taiwan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 02期

关键词：

Snail mucus; anti-cancer; apoptosis; TNBC; chemotherapy; ACHARAN SULFATE; IN-VIVO; NUCLEOLIN; INFLAMMATION; APOPTOSIS; BINDING; PROTEIN; SURFACE; DRUGS; CELLS;

D O I：

10.21873/anticanres.15542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The poor prognosis and chemoresistance of patients with triple-negative breast cancer (TNBC) urge the development of new therapeutic strategies. Snail mucus has shown its ability against inflammation, a process closely related to tumorigenesis, suggesting a potential anti-cancer activity. Materials and Methods: The effect and mechanisms of snail mucus on cell viability were determined by IncuCyte Live-cell analysis and molecular biological methods. The anti-cancer fractions of snail mucus were isolated and identified by medium pressure liquid chromatography (MPLC) and nuclear magnetic resonance (NMR) spectrometry analysis. Results: Snail mucus significantly decreased the viability of TNBC cells with relatively lower cytotoxicity to normal breast epithelial cells and enhanced their response to chemotherapy through activation of Fas signaling by suppressing nucleolin. Two peptide fractions have been identified as the anti-cancer ingredients of the snail mucus. Conclusion: Snail mucus can induce programmed cell death via the extrinsic apoptotic pathway and has therapeutic potential by achieving a chemo-sensitizing effect in TNBCs.

引用

页码：845 / 855

页数：11

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