Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

被引：12
|
作者：
Abdel-Wahab, Bakr F. [1 ,2 ]
Farahat, Abdelbasset A. [3 ]
Awad, Ghada E. A. [4 ]
El-Hiti, Gamal A. [5 ]
机构：
[1] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt
[2] Shaqra Univ, Coll Sci & Humanities, Dept Chem, Duwadimi, Saudi Arabia
[3] Mansoura Univ, Dept Pharmaceut Organ Chem, Fac Pharm, Mansoura 35516, Egypt
[4] Natl Res Ctr, Dept Chem Nat & Microbial Prod, Giza 12622, Egypt
[5] King Saud Univ, Coll Appl Med Sci, Dept Optometry, Cornea Res Chair, POB 10219, Riyadh 11433, Saudi Arabia
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2017年 / 14卷 / 11期
关键词：
Drug design; antimicrobial activity; microorganisms; 3-(thiophen-2-yl)pyrazoles; hydrazides; inhibition zone; PYRAZOLE DERIVATIVES; ANTICANCER;
D O I：
10.2174/1570180814666170327162447
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: A series of novel substituted 3-(thiophen-2-yl) pyrazoles was synthesized efficiently and in high yields using simple and convenient procedures starting from 1-phenyl-3(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde. Methods: The structures of the newly synthesized products were established and their antimicrobial activities were investigated against some bacteria and fungi. Results and Conclusion: The products showed excellent antimicrobial activities against the tested microorganism compared to the standard antibacterial and antifungal drugs.
引用
收藏
页码：1316 / 1323
页数：8
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