Minor Labdane Diterpenes from Marrubium thessalum

被引：6

作者：

Argyropoulou, Catherine ^{[1
]}

Karioti, Anastasia ^{[2
]}

Skaltsa, Helen ^{[1
]}

机构：

[1] Univ Athens, Dept Pharmacognosy & Chem Nat Prod, Sch Pharm, GR-15771 Athens, Greece

[2] Univ Florence, Dept Pharmaceut Sci, IT-50019 Florence, Italy

来源：

CHEMISTRY & BIODIVERSITY | 2011年 / 8卷 / 10期

关键词：

VULGARE;

D O I：

10.1002/cbdv.201000215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new labdane diterpenes, thessalines A, B, and D, 14 beta-hydroxythessaline A, and 14 beta-hydroxythessaline B (1-5, resp.) were isolated from the aerial parts of Marrubium thessalum, along with the known labdane diterpene deacetylvitexilactone (6) and the methoxylated flavones 4',7-dimethylapigenin and salvigenin. (3S,5R)-Loliolide was also found in the same source. Their structures were established by 1D- and 2D-NMR (COSY, HSQC, HMBC, NOESY, and ROESY) and MS analyses. The plant produces a great variety of labdane-type diterpenes, with variations in functionalities, particularly in the side chain. Their structures could be of chemotaxonomic significance for the genus Marrubium.

引用

页码：1880 / 1890

页数：11

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