Copper-Catalyzed Ligand-Free Remote C-H Bond Amidation of 8-Amidoquinolines with N-Fluorobenzenesulfonimide

被引：3

作者：

He, Li ^{[1
]}

Zhu, Yihang ^{[1
]}

Xu, Yongjun ^{[1
]}

机构：

[1] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 47期

关键词：

Amination; 8-Amidoquinolines; C-H Bond; Ligand-free; Organocatalysis; RH(I)-CATALYZED DIRECT ARYLATION; FUNCTIONALIZATION; QUINOLINES; ACTIVATION; AMINATION; OXIDES; SULFONYLATION; ALKYLATION; PYRIDINES; POSITION;

D O I：

10.1002/slct.202102981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed direct C-H bond C5-amidation of 8-amidoquinolines with NFSI has been developed. This catalytic amination process is carried out without any ligands to form various derivatives in moderate to excellent yields using a commercially available Cu(II) as the catalyst under a simple condition. A single-electron transfer (SET)-mediated mechanism was proposed based on the experimental data and a serious of mechanistic studies.

引用

页码：13559 / 13563

页数：5

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