Post-translational modifications and age-related hearing loss

被引：4
|
作者：
Bazard, Parveen [1 ,6 ]
Pineros, Jennifer [1 ,6 ]
Acosta, Alejandro A. [5 ,6 ]
Thivierge, Mark [1 ,6 ]
Paganella, Lauren R. [1 ,6 ]
Zucker, Samuel [1 ,6 ]
Mannering, Freyda L. [3 ,6 ]
Modukuri, Shrikar [4 ,6 ]
Zhu, Xiaoxia [1 ,6 ]
Frisina, Robert D. [1 ,2 ,3 ,7 ]
Ding, Bo [1 ,6 ]
机构：
[1] Univ S Florida, Coll Engn, Dept Med Engn, Tampa, FL 33620 USA
[2] Coll Behav & Commun Sci, Dept Commun Sci & Disorders, Tampa, FL 33620 USA
[3] Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA
[4] Univ S Florida, Biomed Sci Dept Chem, Tampa, FL 33620 USA
[5] Univ Puerto Rico, Sch Med, San Juan, PR 00925 USA
[6] Univ S Florida, Global Ctr Hearing & Speech Res, Tampa, FL 33612 USA
[7] Univ S Florida, Global Ctr Hearing & Speech Res, 3802 Spectrum Blvd,BPB Suite 210, Tampa, FL 33612 USA
来源：
HEARING RESEARCH | 2022年 / 426卷
关键词：
Aging; Post-translational modifications; Neurodegenerative disorders; Auditory system; Age-related Hearing Loss; Cochlea; Inner ear; ACTIVATED PROTEIN-KINASE; COCHLEAR HAIR CELL; QUALITY-OF-LIFE; DNA METHYLATION; NOISE EXPOSURE; EARLY-ONSET; PHOSPHORYLATION; GLYCOSYLATION; EXPRESSION; UBIQUITINATION;
D O I：
10.1016/j.heares.2022.108625
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Post-translational modifications (PTMs) affect nearly all systems of the human body due to their role in protein synthesis and functionality. These reversible and irreversible modifications control the structure, localization, activity, and properties of proteins. For this reason, PTMs are essential in regulating cellular processes and maintaining homeostasis. Diseases such as Alzheimer's, cardiovascular disease, diabetes, cancer, and many others have been linked to dysfunctions of PTMs. Recent research has also shown that irregularities in PTMs can be linked to hearing loss, including age-related hearing loss (ARHL) - the num-ber one communication disorder and one of the top neurodegenerative diseases in our aging population. So far, there has been no FDA approved treatment for ARHL; however, translational studies investigating PTMs involvement in ARHL show promising results. In this review, we summarize key findings for PTMs within the auditory system, the involvement of PTMs with aging and ARHL, and lastly discuss potential treatment options focusing on utilizing PTMs as biomarkers and therapeutic pathway components.(c) 2022 Elsevier B.V. All rights reserved.
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页数：11
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