One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

被引：4

作者：

Cui, Mingyue ^{[1
,2
]}

Wiraja, Christian ^{[2
]}

Qi, Lim Wei ^{[4
]}

Ting, Sharon Chew Wan ^{[2
]}

Jana, Deblin ^{[4
]}

Zheng, Mengjia ^{[2
]}

Hu, Xiao ^{[1
,3
]}

Xu, Chenjie ^{[1
,2
,5
,6
]}

机构：

[1] Nanyang Technol Univ, Nanyang Environm & Water Res Inst, Interdisciplinary Grad Programme, Singapore 637141, Singapore

[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore

[3] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[4] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[5] Natl Dent Ctr Singapore, 5 Second Hosp Ave, Singapore 168938, Singapore

[6] City Univ Hong Kong, Dept Biomed Engn, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China

来源：

NANO RESEARCH | 2020年 / 13卷 / 06期

关键词：

silica nanoparticles; one-step synthesis; surface modification; bacterial & cell labelling; NANOMACHINES; SIZE;

D O I：

10.1007/s12274-020-2775-z

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple molecules including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

引用

页码：1592 / 1596

页数：5

共 20 条

[1] Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine [J].

Ambrogio, Michael W. ;

Thomas, Courtney R. ;

Zhao, Yan-Li ;

Zink, Jeffrey I. ;

Stoddartt, J. Fraser .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :903-913

[2] Folic acid-modified mesoporous silica nanoparticles with pH-responsiveness loaded with Amp for an enhanced effect against anti-drug-resistant bacteria by overcoming efflux pump systems [J].

Chen, Xu ;

Liu, Yanan ;

Lin, Ange ;

Huang, Na ;

Long, Liquan ;

Gang, Ye ;

Liu, Jie .

BIOMATERIALS SCIENCE, 2018, 6 (07) :1923-1935

[3] Detection of Bacteria Using Inkjet-Printed Enzymatic Test Strips [J].

Creran, Brian ;

Li, Xiaoning ;

Duncan, Bradley ;

Kim, Chang Soo ;

Moyano, Daniel F. ;

Rotello, Vincent M. .

ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (22) :19525-19530

[4] In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation [J].

He, Qianjun ;

Zhang, Zhiwen ;

Gao, Fang ;

Li, Yaping ;

Shi, Jianlin .

SMALL, 2011, 7 (02) :271-280

[5] The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses [J].

He, Qianjun ;

Zhang, Jiamin ;

Shi, Jianlin ;

Zhu, Ziyan ;

Zhang, Linxia ;

Bu, Wenbo ;

Guo, Limin ;

chen, Yu .

BIOMATERIALS, 2010, 31 (06) :1085-1092

[6] Physicochemical Characterization and Drug Release of Thermosensitive Hydrogels Composed of a Hyaluronic Acid/Pluronic F127 Graft [J].

Hsu, Shu-Hui ;

Leu, Yann-Lii ;

Hu, Jiuan-Wen ;

Fang, Jia-You .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (05) :453-458

[7] Expanding Anti-Stokes Shifting in Triplet-Triplet Annihilation Upconversion for In Vivo Anticancer Prodrug Activation [J].

Huang, Ling ;

Zhao, Yang ;

Zhang, He ;

Huang, Kai ;

Yang, Jinyi ;

Han, Gang .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (46) :14400-14404

[8] In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites [J].

Li, Zhanjun ;

Zhang, Yuanwei ;

Wu, Xiang ;

Wu, Xiaoqiong ;

Maudgal, Rohit ;

Zhang, Hongwu ;

Han, Gang .

ADVANCED SCIENCE, 2015, 2 (03)

[9] Mesoporous silica nanoparticles in biomedical applications [J].

Li, Zongxi ;

Barnes, Jonathan C. ;

Bosoy, Aleksandr ;

Stoddart, J. Fraser ;

Zink, Jeffrey I. .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) :2590-2605

[10] Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel [J].

Liu, Yutao ;

Li, Kai ;

Pan, Jie ;

Liu, Bin ;

Feng, Si-Shen .

BIOMATERIALS, 2010, 31 (02) :330-338

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