Triflic acid-catalyzed highly stereoselective friedel-crafts aminoalkylation of indoles and pyrroles

被引：84
|
作者：
Abid, Mohammed [1 ]
Teixeira, Liliana [1 ]
Torok, Bela [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Boston, MA 02125 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 05期
关键词：
D O I：
10.1021/ol703095d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient synthesis to both enantiomers of highly enantiomerically enriched alpha-trifluoromethyl-alpha-(heteroaryl)-glycine derivatives via highly stereoselective aminoalkylation of indoles and pyrroles is described. The triflic acid-catalyzed reaction of enantiomeric 3,3,3-trifluoro-pyruvate-alpha-methylbenzyl imines with indoles and pyrroles and the subsequent Pd-catalyzed hydrogenolysis of the methylbenzyl group provided the products in high yields and excellent enantioselectivities.
引用
收藏
页码：933 / 935
页数：3
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