Further utilization of mucohalic acids:: Palladium-free, regioselective etherification and amination of α,β-dihalo γ-methoxycarbonyloxy and γ-acetoxy butenolides

被引：26

作者：

Blazecka, PG ^{[1
]}

Belmont, D ^{[1
]}

Curran, T ^{[1
]}

Pflum, D ^{[1
]}

Zhang, J ^{[1
]}

机构：

[1] Pfizer Inc, Ann Arbor Labs, Chem Res & Dev, Pfizer Global Res & Dev, Ann Arbor, MI 48105 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 26期

关键词：

D O I：

10.1021/ol035994n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Palladium-free etherification and amination of mucohalic acid methyl carbonates le (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield.

引用

页码：5015 / 5017

页数：3

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