Further utilization of mucohalic acids:: Palladium-free, regioselective etherification and amination of α,β-dihalo γ-methoxycarbonyloxy and γ-acetoxy butenolides

被引：26
作者：
Blazecka, PG [1 ]
Belmont, D [1 ]
Curran, T [1 ]
Pflum, D [1 ]
Zhang, J [1 ]
机构：
[1] Pfizer Inc, Ann Arbor Labs, Chem Res & Dev, Pfizer Global Res & Dev, Ann Arbor, MI 48105 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 26期
关键词：
D O I：
10.1021/ol035994n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Palladium-free etherification and amination of mucohalic acid methyl carbonates le (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield.
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收藏
页码：5015 / 5017
页数：3
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