Further utilization of mucohalic acids:: Palladium-free, regioselective etherification and amination of α,β-dihalo γ-methoxycarbonyloxy and γ-acetoxy butenolides

被引:26
作者
Blazecka, PG [1 ]
Belmont, D [1 ]
Curran, T [1 ]
Pflum, D [1 ]
Zhang, J [1 ]
机构
[1] Pfizer Inc, Ann Arbor Labs, Chem Res & Dev, Pfizer Global Res & Dev, Ann Arbor, MI 48105 USA
关键词
D O I
10.1021/ol035994n
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Palladium-free etherification and amination of mucohalic acid methyl carbonates le (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield.
引用
收藏
页码:5015 / 5017
页数:3
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