Association of hypertriglyceridemic waist-to-height ratio and its dynamic status with risk of type 2 diabetes mellitus: The Rural Chinese Cohort Study

被引：4

作者：

Qie, Ranran ^{[1
,2
]}

Li, Quanman ^{[1
,2
]}

Zhao, Yang ^{[2
,4
]}

Han, Minghui ^{[2
]}

Liu, Dechen ^{[2
]}

Guo, Chunmei ^{[2
]}

Zhou, Qionggui ^{[3
]}

Tian, Gang ^{[4
]}

Huang, Shengbing ^{[4
]}

Wu, Xiaoyan ^{[3
]}

Zhang, Yanyan ^{[3
]}

Qin, Pei ^{[3
]}

Li, Honghui ^{[2
]}

Wang, Jian ^{[2
]}

Cheng, Ruirong ^{[2
]}

Lin, Jinchun ^{[2
]}

Sun, Xizhuo ^{[2
]}

Wu, Yuying ^{[3
]}

Li, Yang ^{[3
]}

Yang, Xingjin ^{[4
]}

Zhao, Yang ^{[2
,4
]}

Feng, Yifei ^{[4
]}

Zhang, Ming ^{[3
]}

Hu, Dongsheng ^{[1
,2
]}

机构：

[1] Shenzhen Univ Hlth Sci Ctr, Affiliated Luohu Hosp, Dept Endocrinol, Shenzhen, Guangdong, Peoples R China

[2] Shenzhen Univ Hlth Sci Ctr, Affiliated Luohu Hosp, Study Team Shenzhens Sanming Project, Shenzhen, Guangdong, Peoples R China

[3] Shenzhen Univ Hlth Sci Ctr, Sch Publ Hlth, Shenzhen, Guangdong, Peoples R China

[4] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou, Henan, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2021年 / 179卷

基金：

中国国家自然科学基金;

关键词：

Cohort study; Dynamic status; Hypertriglyceridemic waist-to-height ratio; Type 2 diabetes mellitus; CHRONIC KIDNEY-DISEASE; OBESITY; GLUCOSE; METAANALYSIS; PREVALENCE; PHENOTYPE;

D O I：

10.1016/j.diabres.2021.108997

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To evaluate the risk of type 2 diabetes mellitus (T2DM) in a prospective study with hypertriglyceridemic waist-to-height ratio (HWHtR) and its dynamic status. Methods: We collected data for 12,248 participants >18 years in this study. Cox's proportional-hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for T2DM risk by baseline HWHtR. Multiple logistic regression analysis was used to estimate odds ratios (ORs) and 95% CIs for T2DM risk by transformation in HWHtR. Results: We identified 839 T2DM cases during a median follow-up of 5.92 years. Compared with normal TG level and normal WHtR, T2DM risk was increased with high TG level and high WHtR (aHR 2.04, 95% CI 1.49-2.79). Similar results were observed in subgroup analyses by sex and age. During follow-up, T2DM risk was increased with stable high TG level and high WHtR (aOR 4.45, 95% CI 2.76-7.17) compared with stable normal TG level and normal WHtR. The results above were robust in sensitivity analyses. Conclusions: HWHtR phenotype and its dynamic status were associated with risk of T2DM. Our study suggests that primary prevention and avoiding the appearance of the HWHtR phenotype in the rural Chinese population may reduce the T2DM risk. CO 2021 Published by Elsevier B.V.

引用

页数：8

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