Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models

被引：0
作者：
Herrmann, Lars [1 ,2 ]
Hahn, Friedrich [3 ]
Wangen, Christina [3 ]
Marschall, Manfred [3 ]
Tsogoeva, Svetlana B. [1 ,2 ]
机构：
[1] Friedrich Alexander Univ Erlangen Nurnberg, Organ Chem Chair 1, Nikolaus Fiebiger Str 10, D-91058 Erlangen, Germany
[2] Friedrich Alexander Univ Erlangen Nurnberg, Interdisciplinary Ctr Mol Mat ICMM, Nikolaus Fiebiger Str 10, D-91058 Erlangen, Germany
[3] Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Clin & Mol Virol, Schlossgarten 4, D-91054 Erlangen, Germany
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2022年 / 28卷 / 04期
关键词：
antiviral drug assessment; cell culture-based infection models; morpholine-quinoline hybrids; quinoline compounds; SARS-CoV-2;
D O I：
10.1002/chem.202103861
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The presently ongoing pandemic of human SARS-CoV-2 infections (COVID-19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline-morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture-based inhibitory profile against SARS-CoV-2. Thus, selected quinoline compounds may suggest specific hit-to-lead development.
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