Comparing immunoglobulin A vasculitis (Henoch-Schonlein purpura) in children and adults: a single-centre study from Turkey

被引:40
作者
Batu, E. D. [1 ]
Sari, A. [2 ]
Erden, A. [2 ]
Sonmez, H. E. [1 ]
Armagan, B. [2 ]
Kalyoncu, U. [2 ]
Karadag, O. [2 ]
Bilginer, Y. [1 ]
Akdogan, A. [2 ]
Kiraz, S. [2 ]
Ozen, S. [1 ]
机构
[1] Hacettepe Univ, Fac Med, Dept Pediat, Div Rheumatol, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey
关键词
PREDICTIVE FACTORS; CLINICAL-MANIFESTATIONS; CHILDHOOD; CLASSIFICATION; NEPHRITIS; CRITERIA; OUTCOMES; RELAPSE; DISEASE;
D O I
10.1080/03009742.2018.1448111
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Immunoglobulin A vasculitis/Henoch-Schonlein purpura (IgAV/HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It is the most common primary systemic vasculitis of childhood and is much less common in adults. Our aim was to investigate the differences and similarities between adult and paediatric patients with IgAV/HSP. Method: We retrospectively evaluated the medical records of 35 adult and 159 paediatric (< 18 years old) patients with a clinical diagnosis of IgAV/HSP who were seen at the Departments of Rheumatology and Pediatric Rheumatology, Hacettepe University, Ankara, Turkey. The paediatric and adult patients were classified with IgAV/HSP according to the Ankara 2008 and American College of Rheumatology 1990 criteria, respectively. Results: Upper respiratory tract infection was a common predisposing factor for both adults (34.3%) and children (21.4%). Creatinine and C-reactive protein were higher; and skin biopsy, hypertension, renal involvement, haematuria, proteinuria, and renal insufficiency at diagnosis were more frequent in adults than in children. Thrombocyte count was higher in children than in adults. Follow-up without treatment and complete recovery were more frequent in children, while persistent haematuria, chronic renal failure, relapse, and the use of corticosteroids/azathioprine were more frequent in adults. The only independent predictive factor for relapse was persistent haematuria. Conclusion: Various clinical and laboratory characteristics differ between children and adults with IgAV/HSP. Overall, IgAV/HSP has a self-limiting course in children but represents a more severe form of disease in adults, with more severe renal involvement. Persistent haematuria is a predictive factor for relapse.
引用
收藏
页码:481 / 486
页数:6
相关论文
共 34 条
[1]  
Alfredo CS, 2007, J PEDIAT-BRAZIL, V83, P177, DOI 10.2223/JPED.1595
[2]  
ATKINSON SR, 1976, BRIT J PREV SOC MED, V30, P22
[3]   Age- And Sex-Related Variations in Platelet Count in Italy: A Proposal of Reference Ranges Based on 40987 Subjects' Data [J].
Biino, Ginevra ;
Santimone, Iolanda ;
Minelli, Cosetta ;
Sorice, Rossella ;
Frongia, Bruno ;
Traglia, Michela ;
Ulivi, Sheila ;
Di Castelnuovo, Augusto ;
Goegele, Martin ;
Nutile, Teresa ;
Francavilla, Marcella ;
Sala, Cinzia ;
Pirastu, Nicola ;
Cerletti, Chiara ;
Iacoviello, Licia ;
Gasparini, Paolo ;
Toniolo, Daniela ;
Ciullo, Marina ;
Pramstaller, Peter ;
Pirastu, Mario ;
de Gaetano, Giovanni ;
Balduini, Carlo L. .
PLOS ONE, 2013, 8 (01)
[4]   Henoch-Schonlein purpura in adulthood and childhood - Two different expressions of the same syndrome [J].
Blanco, R ;
MartinezTaboada, VM ;
RodriguezValverde, V ;
GarciaFuentes, M ;
GonzalezGay, MA .
ARTHRITIS AND RHEUMATISM, 1997, 40 (05) :859-864
[5]   Predictive Factors of Relapse in Adult With Henoch-Schonlein Purpura [J].
Byun, Ji-Won ;
Song, Hee-Jin ;
Kim, Lucia ;
Shin, Jeong-Hyun ;
Choi, Gwang-seong .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2012, 34 (02) :139-144
[6]   Henoch-Schonlein purpura in children from northwestern Spain -: A 20-year epidemiologic and clinical study [J].
Calviño, MC ;
Llorca, J ;
García-Porrúa, C ;
Fernández-Iglesias, JL ;
Rodriguez-Ledo, P ;
González-Gay, MA .
MEDICINE, 2001, 80 (05) :279-290
[7]   Relapses in patients with Henoch-Schonlein purpura Analysis of 417 patients from a single center [J].
Calvo-Rio, Vanesa ;
Luis Hernandez, Jose ;
Ortiz-Sanjuan, Francisco ;
Loricera, Javier ;
Palmou-Fontana, Natalia ;
Gonzalez-Vela, Maria C. ;
Gonzalez-Lamuno, Domingo ;
Gonzalez-Lopez, Marcos A. ;
Armesto, Susana ;
Blanco, Ricardo ;
Gonzalez-Gay, Miguel A. .
MEDICINE, 2016, 95 (28)
[8]   Predictors of outcome in Henoch-Schonlein nephritis in children and adults [J].
Coppo, Rosanna ;
Andrulli, Simeone ;
Amore, Alessandro ;
Gianoglio, Bruno ;
Conti, Giovanni ;
Peruzzi, Licia ;
Locatelli, Francesco ;
Cagnoli, Leonardo .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 47 (06) :993-1003
[9]   ADULT HENOCH-SCHONLEIN NEPHRITIS [J].
FAULL, RJ ;
AARONS, I ;
WOODROFFE, AJ ;
CLARKSON, AR .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1987, 17 (04) :396-401
[10]   Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-Schonlein purpura in adults [J].
García-Porrúa, C ;
González-Gay, MA .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1999, 28 (06) :404-412