Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma

被引：64
作者：
Chen, Zhiao [1 ,2 ]
Lu, Xinyuan [3 ]
Wang, Zhichao [4 ,5 ]
Jin, Guangzhi [3 ]
Wang, Qifeng [6 ]
Chen, Di [7 ]
Chen, Taoyang [8 ]
Li, Jinjun [7 ]
Fan, Jia [4 ,5 ]
Cong, Wenming [3 ]
Gao, Qiang [4 ,5 ]
He, Xianghuo [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Shanghai 200433, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Dept Oncol, Shanghai Med Coll, Shanghai 200433, Peoples R China
[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Pathol, Shanghai, Peoples R China
[4] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Shanghai 200433, Peoples R China
[5] Fudan Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Shanghai 200433, Peoples R China
[6] Fudan Univ, Dept Pathol, Shanghai Canc Ctr, Shanghai 200433, Peoples R China
[7] Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes,Renji Hos, Shanghai 200030, Peoples R China
[8] Qi Dong Liver Canc Inst, Qi Dong, Jiangsu, Peoples R China
来源：
ONCOTARGET | 2015年 / 6卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Pyruvate kinase isoform M2; Tripartite motif-containing protein 35; Hepatocellular carcinoma; Prognosis; biomarker; PYRUVATE-KINASE M2; TUMOR M2-PYRUVATE KINASE; CELL-METABOLISM; CANCER; EXPRESSION; GENE; COACTIVATOR; ISOFORM; MARKER; TISSUE;
D O I：
10.18632/oncotarget.2991
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The identification of prognostic markers for hepatocellular carcinoma (HCC) is needed for clinical practice. Tripartite motif-containing 35 (TRIM35) is a tumor suppressor of HCC. TRIM35 inhibits phosphorylation of pyruvate kinase isoform M2 (PKM2), which is involved in aerobic glycolysis of cancer cells. We found that expression of PKM2 was significantly increased in HCC tissues. This overexpression of PKM2 was correlated with a high TNM stage and level of vascular invasion. Patients with HCC who were positive for PKM2 expression and negative for TRIM35 expression had shorter overall survival and time to recurrence than patients who were negative for PKM2 and positive for TRIM35. Furthermore, PKM2/TRIM35 combination was an independent and significant risk factor for recurrence and survival. In conclusion, PKM2 (+) and TRIM35 (-) contribute to the aggressiveness and poor prognosis of HCC. PKM2/TRIM35 expression could be a biomarker for the prognosis of HCC and target for cancer therapy.
引用
收藏
页码：2539 / 2548
页数：10
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