Synthesis and Investigation of Antidiabetic Response of New Coumarin Derivatives Against Streptozotocin Induced Diabetes in Experimental Rats

A new series of coumarin analogs (1a - 1g) were designed and synthesized. The chemical structures of all compounds were elucidated by IR, H-1 NMR, C-13 NMR, and mass spectroscopy techniques. The synthesized compounds were investigated for their anti-diabetic activity against streptozotocin (STZ) induced diabetes in rats. The albino rats were selected to observe the oral glucose tolerance test (OGTT) by oral intake of aqueous glucose solution (4 g/kg body weight) in normal rats and estimate the blood glucose level after administration of compounds 1e - 1f at 50 and 100 mg/kg, and standard drug glibenclamide at 0.6 mg/kg body weight. Antidiabetic activity was studied by estimating the blood glucose level in diabetic rats. The results showed that all the synthesized coumarin analogs 1a - 1g exhibited antidiabetic potential. Compounds 1e - 1f produced eminent antidiabetic effects in STZ induced diabetic rats.