Development of a high-performance, enterprise-level, multimode LC-MS/MS autosampler for drug discovery

被引：15
|
作者：
Kapinos, Brendon [1 ]
Liu, JianHua [1 ]
Piotrowski, Mary [1 ]
Keefer, Julie [1 ]
Holder, Brian [1 ]
Janiszewski, John [1 ]
Zhang, Hui [1 ]
Troutman, Matt [1 ]
机构：
[1] Pfizer Inc, World Wide Res & Dev, Hit Discovery & Optimizat Group, Eastern Point Rd, Groton, CT 06340 USA
来源：
BIOANALYSIS | 2017年 / 9卷 / 21期
关键词：
ADME; Cassette analysis; high-throughput; LC-MS/MS; peak capacity; CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY; HIGH-THROUGHPUT; LIQUID-CHROMATOGRAPHY; GRADIENT ELUTION; PEAK-CAPACITY; HIGH-SPEED; BIOANALYSIS; ASSAY; PLATFORM; SAMPLES;
D O I：
10.4155/bio-2017-0149
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：1643 / 1654
页数：12
相关论文
共 50 条
  • [1] LC-MS aids drug discovery
    不详
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2008, 27 (05) : IX - IX
  • [2] Metabolite identification by LC-MS: Applications in drug discovery and development
    Hop, CECA
    Prakash, C
    IDENTIFICATION AND QUANTIFICATION OF DRUGS, METABOLITES AND METABOLIZING ENZYMES BY LC-MS, 2005, 6 : 123 - 158
  • [3] LC-MS/MS approach to 'metabonomics' - What can it do for drug discovery/development?
    Shockcor, JP
    Nichols, A
    Antti, H
    Plumb, RS
    Castro-Perez, JM
    Major, H
    Preece, S
    DRUG METABOLISM REVIEWS, 2003, 35 : 1 - 1
  • [4] Development of LC-MS/MS and LC-MS/TOF methods to study trends in drug abuse and drug adulteration
    Lynch, K. L.
    Petrie, M. S.
    Wu, A. H. B.
    THERAPEUTIC DRUG MONITORING, 2011, 33 (04) : 470 - 470
  • [5] In vitro DMPK screening in drug discovery, role of LC-MS/MS
    Chu, IH
    Nomeir, AA
    Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, 2005, 6 : 105 - 122
  • [6] Principles and applications of LC-MS in new drug discovery
    Korfmacher, WA
    DRUG DISCOVERY TODAY, 2005, 10 (20) : 1357 - 1367
  • [7] Quantifying vemurafenib in dried blood spots using high-performance LC-MS/MS
    Nijenhuis, Cynthia M.
    Rosing, Hilde
    Schellens, Jan H. M.
    Beijnen, Jos H.
    BIOANALYSIS, 2014, 6 (23) : 3215 - 3224
  • [8] High-performance method to detection of Klebsiella pneumoniae Carbapenemase in Enterobacterales by LC-MS/MS
    Otávio A. Lovison
    Renata B. Rau
    Daiana Lima-Morales
    Evellyn K. Almeida
    Marina N. Crispim
    Fabiano Barreto
    Afonso L. Barth
    Andreza F. Martins
    Brazilian Journal of Microbiology, 2020, 51 : 1029 - 1035
  • [9] High-performance method to detection of Klebsiella pneumoniae Carbapenemase in Enterobacterales by LC-MS/MS
    Lovison, Otavio A.
    Rau, Renata B.
    Lima-Morales, Daiana
    Almeida, Evellyn K.
    Crispim, Marina N.
    Barreto, Fabiano
    Barth, Afonso L.
    Martins, Andreza F.
    BRAZILIAN JOURNAL OF MICROBIOLOGY, 2020, 51 (03) : 1029 - 1035
  • [10] Simultaneous determination of four antibiotics in human plasma by high-performance LC-MS/MS: application to therapeutic drug monitoring
    Liu, Hongchuan
    Yu, Xiaojia
    Hu, Ting
    Han, Feifei
    An, Zhuoling
    Zhao, Rui
    BIOANALYSIS, 2023, 15 (05) : 269 - 282
12345