Development of a high-performance, enterprise-level, multimode LC-MS/MS autosampler for drug discovery

被引：15

作者：

Kapinos, Brendon ^{[1
]}

Liu, JianHua ^{[1
]}

Piotrowski, Mary ^{[1
]}

Keefer, Julie ^{[1
]}

Holder, Brian ^{[1
]}

Janiszewski, John ^{[1
]}

Zhang, Hui ^{[1
]}

Troutman, Matt ^{[1
]}

机构：

[1] Pfizer Inc, World Wide Res & Dev, Hit Discovery & Optimizat Group, Eastern Point Rd, Groton, CT 06340 USA

来源：

BIOANALYSIS | 2017年 / 9卷 / 21期

关键词：

ADME; Cassette analysis; high-throughput; LC-MS/MS; peak capacity; CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY; HIGH-THROUGHPUT; LIQUID-CHROMATOGRAPHY; GRADIENT ELUTION; PEAK-CAPACITY; HIGH-SPEED; BIOANALYSIS; ASSAY; PLATFORM; SAMPLES;

D O I：

10.4155/bio-2017-0149

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1643 / 1654

页数：12

共 37 条

[1]

Bateman KP, 2013, BIOANALYSIS, V5, P1783, DOI [10.4155/bio.13.162, 10.4155/BIO.13.162]

[2]

Bi YA, 2017, AAPS J, V19, P787, DOI 10.1208/s12248-017-0051-2

[3] Sample reduction strategies in discovery bioanalysis [J].

Cai, Xianmei ;

Zhang, Jun ;

Shou, Wilson Z. .

BIOANALYSIS, 2013, 5 (13) :1691-1701

[4]

COLE MJ, 2002, PRACT SPECTROSC SERI, V32, P211

[5] .Development of a Rapid Microbore Metabolic Profiling Ultraperformance Liquid Chromatography-Mass Spectrometry Approach for High-Throughput Phenotyping Studies [J].

Gray, Nicola ;

Adesina-Georgiadis, Kyrillos ;

Chekmeneva, Elena ;

Plumb, Robert S. ;

Wilson, Ian D. ;

Nicholson, Jeremy K. .

ANALYTICAL CHEMISTRY, 2016, 88 (11) :5742-5751

[6]

Halladay Jason S, 2011, Drug Metab Lett, V5, P220

[7] High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models [J].

Hop, Cornelis E. C. A. ;

Cole, Mark J. ;

Davidson, Ralph E. ;

Duignan, David B. ;

Federico, James ;

Janiszewski, John S. ;

Jenkins, Kelly ;

Krueger, Suzanne ;

Lebowitz, Rebecca ;

Liston, Theodore E. ;

Mitchell, Walter ;

Snyder, Mark ;

Steyn, Stefan J. ;

Soglia, John R. ;

Taylor, Christine ;

Troutman, Matt D. ;

Umland, John ;

West, Michael ;

Whalen, Kevin M. ;

Zelesky, Veronica ;

Zhao, Sabrina X. .

CURRENT DRUG METABOLISM, 2008, 9 (09) :847-853

[8]

Janiszewski J, 2012, BIOANALYSIS, V4, P1039, DOI [10.4155/BIO.12.87, 10.4155/bio.12.87]

[9] Perspectives on Bioanalytical Mass Spectrometry and Automation in Drug Discovery [J].

Janiszewski, John S. ;

Liston, Theodore E. ;

Cole, Mark J. .

CURRENT DRUG METABOLISM, 2008, 9 (09) :986-994

[10] A high capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening [J].

Janiszewski, JS ;

Rogers, KJ ;

Whalen, KM ;

Cole, MJ ;

Liston, TE ;

Duchoslav, E ;

Fouda, HG .

ANALYTICAL CHEMISTRY, 2001, 73 (07) :1495-1501

← 1 2 3 4 →