Reference interval for urinary neutrophil gelatinase-associated lipocalin in healthy adults in Jiangsu region in Eastern China: a multicenter study

被引：1

作者：

Liu, Qian ^{[1
,2
]}

Chen, Xiaochun ^{[3
]}

Hang, Huan ^{[4
]}

Xu, Zhihui ^{[5
]}

Yang, Fumeng ^{[1
,2
]}

机构：

[1] Second Peoples Hosp Lianyungang, Dept Lab Med, Lianyungang, Peoples R China

[2] Jiangsu Univ, Lianyungang Hosp, Dept Lab Med, Lianyungang, Peoples R China

[3] Taizhou Second Peoples Hosp, Dept Lab Med, Taizhou, Peoples R China

[4] Yancheng 1 Peoples Hosp, Dept Lab Med, Yancheng, Peoples R China

[5] Lanyuan Community Hlth Serv Ctr Xuanwu Dist, Dept Lab Med, Nanjing, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2022年 / 16卷 / 01期

关键词：

biomarker acute kidney injury; latex-enhanced immunoturbidimetry; reference interval; urinary neutrophil gelatinase-associated lipocalin; ACUTE KIDNEY INJURY; ESTABLISHMENT; BIOMARKERS; PERFORMANCE; NGAL;

D O I：

10.2217/bmm-2021-0464

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We explored the concentrations of urinary neutrophil gelatinase-associated lipocalin (NGAL) in healthy adults in the Jiangsu region in Eastern China and established a reference interval using latex-enhanced immunoturbidimetry to provide important guidelines for the interpretation and application of urinary NGAL in clinical practice. Methods: In total, 1970 eligible subjects from four regions were included in this study. The urinary NGAL levels were measured using an AU5800 automatic biochemical analyzer with its matched reagents. The urinary NGAL reference interval was established using the one-sided percentile method (95th percentile). Results: The urinary NGAL data were non-normally distributed. The urinary NGAL levels were not significantly different by sex or age. Therefore, the urinary NGAL reference interval in healthy adults in the Jiangsu region in Eastern China was <87.5 ng/ml (95th percentile of the upper limit). Conclusion: Urinary NGAL reference interval will play an important role in promoting the clinical value of urinary NGAL.

引用

页码：23 / 30

页数：8

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[31] Urinary neutrophil gelatinase-associated lipocalin: potential biomarker for late-onset sepsis [J].

Pynn, Jennifer M. ;

Parravicini, Elvira ;

Saiman, Lisa ;

Bateman, David A. ;

Barasch, Jonathan M. ;

Lorenz, John M. .

PEDIATRIC RESEARCH, 2015, 78 (01) :76-81

[32] Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Are Not Associated With Serum Redox Parameters in Amateur Athletes After an Ultramarathon [J].

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Correia, Andre Luis Lima ;

de Matos, Robson Salviano ;

Nunes Filho, Julio Cesar Chaves ;

Daher, Elisabeth De Francesco ;

Pinto, Flavio Henrique Macedo ;

de Oliveira, Ariclecio Cunha ;

Ceccatto, Vania Marilande ;

Fortunato, Rodrigo Soares ;

de Carvalho, Denise Pires .

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[33] Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) and contrast-induced acute kidney injury after coronary angiogram [J].

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Descombes, Eric ;

Magnin, Jean-Luc ;

Gachet, Magali ;

Hemett, Ould Maouloud ;

Hayoz, Daniel ;

Stolt, Valerie ;

Baeriswyl, Gerard ;

Stauffer, Jean-Christophe ;

Goy, Jean-Jacques ;

Togni, Mario ;

Cook, Stephane .

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[34] Urinalysis is more specific and urinary neutrophil gelatinase-associated lipocalin is more sensitive for early detection of acute kidney injury [J].

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Semret, Merfake H. ;

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Bryant, Sandra C. ;

Kashani, Kianoush B. ;

Larson, Timothy S. ;

Lieske, John C. .

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[35] Neutrophil Gelatinase-Associated Lipocalin: A Biomarker for Early Diagnosis of Urinary Tract Infections in Infants [J].

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Kotula, Iwona ;

Demkow, Urszula ;

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[36] Urinary neutrophil gelatinase-associated lipocalin and clinical outcomes in chronic kidney disease patients [J].

Lin, Hugo You-Hsien ;

Hwang, Daw-Yang ;

Lee, Su Chu ;

Kuo, Hung-Tien ;

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Chang, Jer-Ming ;

Tsai, Jer-Chia ;

Hung, Chi-Chih ;

Hwang, Shang-Jyh ;

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[37] Urine neutrophil gelatinase-associated lipocalin and other biomarkers in infants with urinary tract infection and in febrile controls [J].

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Jodal, Ulf ;

Barregard, Lars ;

Hansson, Sverker .

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[38] Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection [J].

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Beauchamp, Guy ;

Lapointe, Catherine .

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[39] Urinary Neutrophil Gelatinase-Associated Lipocalin Values in Preterm Neonates: A Systematic Review and Meta-analysis [J].

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Starr, Michelle C. ;

Slagle, Cara ;

Krawczeski, Catherine ;

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[40] Reference values for urinary neutrophil gelatinase-associated lipocalin (NGAL) in pediatric age measured with a fully automated chemiluminescent platform [J].

Cangemi, Giuliana ;

Storti, Simona ;

Cantinotti, Massimiliano ;

Fortunato, Antonio ;

Emdin, Michele ;

Bruschettini, Matteo ;

Bugnone, Daniela ;

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