Lymph node stromal cells: subsets and functions in health and disease

被引：26

作者：

Grasso, C. ^{[1
,2
]}

Pierie, C. ^{[1
,2
]}

Mebius, R. E. ^{[3
]}

van Baarsen, L. G. M. ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Amsterdam Infect & Immun Inst, Dept Rheumatol & Clin Immunol, Dept Expt Immunol,Amsterdam UMC, Amsterdam, Netherlands

[2] Acad Med Ctr, Amsterdam Rheumatol & Immunol Ctr ARC, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Amsterdam Infect & Immun Inst, Dept Mol Cell Biol & Immunol, Amsterdam UMC, Amsterdam, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 10期

关键词：

FIBROBLASTIC RETICULAR CELLS; FOLLICULAR DENDRITIC CELLS; PERIPHERAL TISSUE ANTIGEN; ENDOTHELIAL-CELLS; CONDUIT SYSTEM; AFFERENT LYMPH; T-CELLS; EXPRESSION; TRAFFICKING; RECEPTORS;

D O I：

10.1016/j.it.2021.08.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymph nodes (LNs) aid the interaction between lymphocytes and antigenpresenting cells, resulting in adequate and prolonged adaptive immune responses. LN stromal cells (LNSCs) are crucially involved in steering adaptive immune responses at different levels. Most knowledge on LNSCs has been obtained from mouse studies, and few studies indicate similarities with their human counterparts. Recent advances in single-cell technologies have revealed significant LNSC heterogeneity among different subsets with potential selective functions in immunity. This review provides an overview of current knowledge of LNSCs based on human and murine studies describing the role of these cells in health and disease.

引用

页码：920 / 936

页数：17

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