Isolation of chemical constituents with anti-inflammatory activity from Reineckia carnea herbs

被引：10

作者：

Xu, Xu ^{[1
]}

Tan, Ting ^{[1
,2
]}

Zhang, Jing ^{[1
]}

Li, Zhi-Feng ^{[1
,2
]}

Yang, Shi-Lin ^{[1
,2
]}

Wen, Quan ^{[1
]}

Feng, Yu-Lin ^{[1
,2
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Natl Pharmaceut Engn Ctr NPEC Solid Preparat Chin, Nanchang 330004, Jiangxi, Peoples R China

[2] State Key Lab Innovat Drug & Efficient Energy Sav, Nanchang 330006, Jiangxi, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 04期

关键词：

Reineckia carnea; structure identification; anti-inflammatory activity; STEROIDAL GLYCOSIDES; INFLAMMATORY MEDIATORS; TRITERPENE SAPONINS;

D O I：

10.1080/10286020.2019.1575818

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new saponins (1-3), a new natural product (4) and six other known compounds (5-10) were isolated from the whole Reineckia carnea plant. Their structures were established by comparison of their NMR spectra and MS data with literature data. In addition, all the isolated compounds were evaluated in vitro for anti-inflammatory activities against LPS-stimulated nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 1-4 exhibited anti-inflammatory activities with IC50 values of 37.5 mu M, 31.4 mu M, 34.6 mu M, and 56.1 mu M, respectively. Furthermore, compounds 5-10 showed anti-inflammatory activities with IC50 values ranging from 20.3 to 42.9 mu M.

引用

页码：303 / 315

页数：13

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