A 1,5-benzothiazepine synthesis

被引：27
作者：
Phippen, Christopher B. W. [1 ]
McErlean, Christopher S. P. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 13期
关键词：
Benzothiazepine; Heterocyclic chemistry; Aqueous chemistry; N-Acylpyrrole; PHARMACOLOGICAL-PROPERTIES; AQUEOUS-MEDIA; ARYL IODIDES; CATALYSIS; DILTIAZEM; WATER; CLENTIAZEM; ARYLATION; MECHANISM;
D O I：
10.1016/j.tetlet.2011.01.098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The pharmaceutically active compound (+/-)-thiazesim was synthesized in four steps and 62% overall yield. This new approach to biologically relevant benzothiazepine ring systems features the use of water as a solvent, co-solvent or catalyst in three of the four steps. (c) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1490 / 1492
页数：3
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