Microneedle based transcutaneous delivery of low molecular weight heparin

被引:6
作者
Zafar, Saman [1 ]
Hassan, Sana [1 ]
Mudassir, Jahanzeb [1 ]
Hussain, Amjad [2 ]
Abbas, Nasir [2 ]
Latif, Sumera [3 ]
Ali, Ejaz [2 ]
Arshad, Muhammad Sohail [1 ]
机构
[1] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan
[2] Univ Punjab, Coll Pharm, Lahore, Pakistan
[3] Lahore Coll Women Univ, Fac Pharmaceut & Allied Hlth Sci, Inst Pharm, Lahore, Pakistan
关键词
Microneedles; transdermal drug delivery; low molecular weight heparin; poly vinyl alcohol;
D O I
10.36721/PJPS.2021.34.3.SUP.1165-1170.1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study aimed to fabricate and characterize polymeric microneedle patches for rapid and non-invasive administration of enoxaparin across skin layers. The patches comprising of PVA, sorbitol and enoxaparin sodium were prepared by employing micromolding technique. Formulated patches were characterized physicochemically by folding endurance, dimensional analysis and swelling study, morphologically by optical and scanning electron microscopy and thermally by thermogravimetric analysis. Moreover, performance efficiency of prepared polymeric device was analyzed by in-vitro drug release study and piercing ability. Prepared patches showed appropriate dimensions and folding endurance (i.e., similar to 1100) indicating satisfactory integrity of polymeric device. Patches exhibited appropriately distanced needles with pointed tips in optical and scanning electron microscopy analysis. Thermogravimetric analysis proved thermal stability of formulation ingredients and prepared patches. Swelling percentage was >110 % suggesting that prepared formulation would allow penetration of physiological fluids in its polymeric network. Maximum (similar to 89%) drug was released within similar to 2 hours during in-vitro release study. In-vitro piercing ability experiments suggested that prepared patches successfully breached skin barrier stratum corneum. It is concluded that prepared microneedle device can serve as a potential alternative of currently employed invasive parenteral route for rapid and efficient administration of enoxaparin sodium in the systemic circulation.
引用
收藏
页码:1165 / 1170
页数:6
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