Design and Synthesis of Some Novel 4-(4-substituted aryl) Semicarbazones as Anticonvulsant Agents

被引：4
作者：
Singh, Anita [1 ]
Pande, C. [1 ]
Gahtori, P. [1 ]
Pandeya, S. N. [2 ]
Stables, J. P. [3 ]
机构：
[1] Kumaun Univ, Dept Pharm, Bhimtal 263002, India
[2] Saroj Inst Pharm, Lucknow 222001, Uttar Pradesh, India
[3] Natl Inst Neurol Disorders & Stroke, Epilepsy Branch, NIH, Bethesda, MD 20892 USA
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 72卷 / 03期
关键词：
Anticonvulsant; hydrogen bonding domain; lipophilic aryl/alkyl ring; 4-substituted semicarbazone; ANTIEPILEPTIC DRUG;
D O I：
10.4103/0250-474X.70485
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the present study, a series of 4-(4-substituted aryl) semicarbazones were synthesized from substituted anilines and subsequently evaluated for their anticonvulsant activities. The anticonvulsant activities were established by the anticonvulsant drug development (ADD) programme NIH, USA using experimental animal, adult male FCM mice (20-25 g) and adult Sprague-Dawley rats (100-150 g) and screened against electroshock seizure, subcutaneous metrazole and minimal neurotoxicity tests in mice. Compound 7 was found equipotent to carbamazepine in both MES and ScPTZ tests. This study has highlighted the importance of distal alkyl chain which influences the anticonvulsant activity.
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收藏
页码：363 / U367
页数：5
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