The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity

被引：13

作者：

van Galen, Katy A. ^{[1
]}

Booij, Jan ^{[2
]}

Schrantee, Anouk ^{[2
]}

Adriaanse, Sofie M. ^{[2
]}

Unmehopa, Unga A. ^{[1
]}

Fliers, Eric ^{[1
]}

Schwartz, Gary J. ^{[3
]}

DiLeone, Ralph J. ^{[4
]}

ter Horst, Kasper W. ^{[1
]}

la Fleur, Susanne E. ^{[1
,5
,6
]}

Serlie, Mireille J. ^{[1
]}

机构：

[1] Amsterdam Univ Med Ctr, Dept Endocrinol & Metab, Locat AMC, K2-283,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Amsterdam Univ Med Ctr, Dept Radiol & Nucl Med, Locat AMC, Amsterdam, Netherlands

[3] Albert Einstein Coll Med, Fle Inst Diabet & Metab, Dept Med, Bronx, NY USA

[4] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[5] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Clin Chem, Lab Endocrinol,Amsterdam Neurosci, Amsterdam, Netherlands

[6] Inst Royal Netherlands Acad Arts & Sci KNAW, Netherlands Inst Neurosci, Amsterdam, Netherlands

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2021年 / 123卷

关键词：

Obesity; Food intake; Fasting; Serotonin; Dopamine; SPECT; FOOD-INTAKE; DOPAMINE TRANSPORTER; MONOAMINE TRANSPORTERS; I-123-FP-CIT SPECT; INSULIN-RESISTANCE; EATING BEHAVIOR; BODY-WEIGHT; HUMAN-BRAIN; FATTY-ACID; REWARD;

D O I：

10.1016/j.metabol.2021.154839

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting influences these systems or if such effects are altered in humans with obesity. We therefore aimed to evaluate the effects of fasting on hypothalamic/thalamic serotonin transporter (SERT) and striatal dopamine transporter (DAT) availability in lean subjects and subjects with obesity. Methods: In this randomized controlled cross-over trial, we assessed the effects of 12 vs 24 h of fasting on SERT and DAT availability in the hypothalamus/thalamus and striatum, respectively, using SPECT imaging in 10 lean men and 10 men with obesity. Results: As compared with the 12-h fast, a 24-h fast increased hypothalamic SERT availability in lean men, but not in men with obesity. We observed high inter-individual variation in the effects of fasting on thalamic SERT and striatal DAT, with no differences between lean men and those with obesity. In all subjects, fasting-induced increases in circulating free fatty acid (FFA) concentrations were associated with an increase in hypothalamic SERT availability and a decrease in striatal DAT availability. Multiple regression analysis showed that changes in plasma insulin and FFAs together accounted for 44% of the observed variation in striatal DAT availability. Conclusion: Lean men respond to prolonged fasting by increasing hypothalamic SERT availability, whereas this response is absent in men with obesity. Inter-individual differences in the adaptations of the cerebral serotonergic and dopaminergic systems to fasting may, in part, be explained by changes in peripheral metabolic signals of fasting, including FFAs and insulin. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页数：8

共 81 条

[51] Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production [J].