Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

被引：6
|
作者：
Marcos, Caroline Maria [1 ]
de Oliveira, Haroldo Cesar [1 ]
Assato, Patricia Akemi [1 ]
de Andrade, Cleverton Roberto [2 ]
Fusco-Almeida, Ana Marisa [1 ]
Soares Mendes-Giannini, Maria Jose [1 ]
机构：
[1] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, Lab Micol Clin, Campus Araraquara, Araraquara, SP, Brazil
[2] Univ Estadual Paulista UNESP, Fac Odontol Araraquara, Dept Fisiol & Patol, Araraquara, SP, Brazil
来源：
MEDICAL MYCOLOGY | 2019年 / 57卷 / 07期
基金：
巴西圣保罗研究基金会;
关键词：
Paracoccidioides brasiliensis: 14-3-3 protein; virulence in murine model; pneumocytes apoptosis; APOPTOSIS;
D O I：
10.1093/mmy/myy112
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.
引用
收藏
页码：900 / 904
页数：5
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